+1 (629)348-3199Contribution of the blood biochemical factors, body composition and genetics to low back pain manifestation in complex Arab pedigrees
Joint Event on 3rd International Conference on Spine and Spine Disorders & International Conference on Addiction Research and Therapy
November 26-27, 2018 | Dubai, UAE
Nader Tarabeih, Adel Shalata, Svetlana Trofimov, Alexander Kalinkovich and Gregory Livshits
Tel-Aviv University, Israel The Simon Winter Institute for Human Genetics, Bnai Zion Medical Center, Israel
Scientific Tracks Abstracts : J Neurol Neurorehabil Res
Abstract:
Objective: Evidence has suggested that the development of
low back pain (LBP) is often associated with obesity, muscle
loss and sarcopenia. The mechanisms of these associations
remain unclear. To clarify this, we measured circulating levels
of a selected panel of soluble factors, presumably involved in
the pathogenesis of obesity and sarcopenia, and correlated
them with several LBP-related characteristics, considering body
composition, familial effects and other relevant covariates.
Methods: The cross-sectional study comprised of 1078 Arab-
Israeli individuals. Patients were recruited based on self-reported
LBP. Body composition variables (including fat and muscle mass
measurements) assessed by bioelectrical impedance analysis
(BIA) and anthropometric measurements, scoliosis as measured
by scoliometer, and plasma levels of several cytokines by ELISA
method were collected. Statistical analyses accounted for familial
composition of the sample and possible putative genetic effects.
Results: LBP affected individuals were significantly older, and
showed increased obesity, decreased skeletal mass, and a
significant correlation with spinal scoliosis when compared
to healthy controls. Putative genetic factors were significantly
associated with the age of onset of LBP, regardless of sciatic
pain. Using univariate analyses, plasma concentrations of GDF-
15, leptin, chemerin and follistatin were found to be significantly
elevated in the LBP-affected groups (with or without sciatic
pain) and were highly significantly (p<0.001) associated with
other LBP-related phenotypes, specifically, disease duration,
disability and physician consultation. However, following
adjustment for age, sex, body composition, and putative genetic
factors, only associations between GDF-15, LBP disability
and medical consulting phenotypes, remained significant.
Conclusions: For the first time, we report a significant
and independent association between plasma GDF-15
concentrations and LBP-associated disability. Longitudinal studies
are recommended to determine whether GDF-15 could be a
novel therapeutic target for prevention and/or treatment of LBP.
Biography:
Nader Tarabeih is a PhD student in the Department of Anatomy and Anthropology in the Tel-Aviv University, under the supervision of professor Gregory Livshits. His PhD project on Complex Arab pedigrees was consisting of 1104 volunteer individuals belonging to 28 complex Arab pedigrees with high prevalence of Low Back Pain (LBP). The advantage of a huge sample allowed Nader to accurately estimate contribution of the putative genetic factors to the manifestation of LBP, represented in his first manuscript entitled “Genetic, Body Composition and Demographic Risk Factors of Low Back Pain in Complex Arab Pedigrees” submitted for publication in The Clinical Journal of pain. The second manuscript, in which detailed “Growth and differentiation factor 15 (GDF-15) is a biomarker for low back pain-associated disability”, is in preparation. Nader recently participated in BIRAX Ageing Council 2018 which was in London.
E-mail: nadertar@gmail.com
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