ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF WILD ORIGANUM SYRIACUM ESSENTIAL OIL COMMONLY USED IN THE WEST BANK

doi:10.4066/2249-622X-C2-006

ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF WILD ORIGANUM SYRIACUM ESSENTIAL OIL COMMONLY USED IN THE WEST BANK

Joint Event on International Conference on PHARMACEUTICAL CHEMISTRY & DRUG DISCOVERY & Global Congress on TOXICOLOGY AND PHARMACOLOGY
September 10-11 , 2018 | Dublin , Ireland

Mayadah Bashir Shehadeh

The University of Jordan, Jordan

Posters & Accepted Abstracts : Asian J Biomed Pharmaceut Sci

DOI: 10.4066/2249-622X-C2-006

Abstract:

Origanum syriacum (O syriacum) is a very popular edible and medicinal plant in the East Mediterranean countries. The current study employed microwave-ultrasonic assisted hydro distillation (MAUHD) to produce EO from four wild O syriacum samples. Gas chromatography coupled with mass spectrometer detector (GC/MS) was used for phytochemical analysis. Assessment of their antibacterial and antioxidant potentials in vitro was carried out. Sesquiterpenes (24-39%) α-humulene and caryophellene in addition to oxygenated monoterpenes (26-41%) thymol and carvacrol represent the bulk of phytochemicals detected by GC-MS analysis. Thymol-rich EOs were found to be most effective against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) (MIC 0.4 mg/mL). Carvacrol and α-humulene rich chemo type EO from Bethlehem, exhibited the highest inhibitory effect of Pseudomonas aeruginosa (MIC of 1.6 mg/mL). Interestingly, γ-terpinene-rich EO from Jerusalem and Bethlehem showed promising antibacterial properties against Enterococcus faecium and MRSA (MIC 100 and 200μg/mL respectively). In conclusion, the current study supports the use of MAUHD as a time-saving, cost-effective, environment-friendly method for production of high quality O syriacum EO for potential use in the treatment, prevention and adjuvant therapy against bacterial infections without compromising the quantity.

Biography:

PDF HTML