A comparative study of co-processed natural disintegrants with the commonly used disintegrants
2nd International Conference and Exhibition on Pharmaceutics and Advanced Drug Delivery Systems
July 05-06, 2019 | Paris, France
Jaydeep Patel and Jiten Shanishchara
B K Mody Government Pharmacy College, India
Scientific Tracks Abstracts : Asian J Biomed Pharmaceut Sci
The present research work deals with preparing spray dried co-processed natural disintegrant which has an excellent disintegration efficiency. Based on the preprimary trial results, chitin and corn starch were selected as an excipients to be co-processed and range of the processing parameters for spray drying were optimized. 32 Full factorial design was applied, where ratio of chitin:corn starch (X1) & In-let air temperature (X2) were selected as independent factors. Here wetting time, water absorption ratio and Invitro disintegration were selected as dependent response variables. Comparative evaluation of the optimized coprocessed natural disintegrant, Sodium starch glycolate (SSG) and Cross carmelose sodium (CCS) were carried out by formulating tablets with the propranolol hydrochloride and Ibuprofen. Lowest In-vitro disintegration time, wetting time and water absorption ratio for the Lactose monohydrate and D- Mannitol tablets were 29 sec, 30 sec, 75.12% and 31 sec, 28 sec, 80.07%. Almost similar results were obtained in the tablets with Lactose monohydrate and D-Mannitol as a diluent. Optimized batch having Chitin:corn starch in a 50:50 ratio when spray dried at In-let air temperature of 180 °C, provides co-processed natural disintegrant having excellent disintegration efficiency. All the evaluation parameters of the optimized batch met the acceptance criteria. In-vitro disintegration time of formulated propranolol hydrochloride tablets with optimized co-processed natural disintegrant, SSG and CCS were 31 sec, 58 sec & 52 sec respectively. In-vitro disintegration time of formulated Ibuprofen tablets with optimized co-processed natural disintegrant, SSG and CCS were 25 sec, 33 sec & 30 sec respectively. Stability data of all tablets shows no significant change during stability period & they were in an acceptable range. It was found to have versatile disintegration efficiency without being affected by the type of diluent used and without being affected by the class/dose of active pharmaceutical ingredient to be used with. Order of the disintegration efficiency was Coprocessed natural disintegrant > CCS > SSG.
Jaydeep Patel has completed his PhD at the age of 29 from Hemchandracharya North Gujarat University, India. He is working as Class-II Senior Lecturer at B K Mody Government Pharmacy College, India. affiliated with Gujarat Technological University, India. He has more than 10 years of teaching and research experience. His area of research is preformulation and novel drug delivery system. He has published and presentated various research papers in many National and International conferences.
E-mail: [email protected]