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allied
academies
Journal of Timely Topics in Clinical Immunology | Volume 2
July 26-28, 2018 | Moscow, Russia
Immunology
11
th
Annual Congress on
A key to the backdoor into the castle: The clinical ramifications of immunoediting driven by antigenic
competition
Michael G Hanna
Vaccinogen Inc., USA
O
ver the last decade the field of cancer biology has gained
considerable data on genomic heterogeneity. This
situation creates challenges and possibly opportunities for
cancer treatment. The evolution of the tumor at all stages also
requires the growing malignancy to confront and avoid the
immune system. What we describe here is the interaction of
two immune phenomena that work together to change the
characteristics of the tumor, i.e., antigenic competition and
immuneediting. These twosystemsaremutually functional, and
their interaction is capable of altering the characteristics of the
tumor for protection and survival in an immune competent host
aswell as restricting thediversityof the tumor clones. Therefore,
the final outcome of these interactions can also become the
key to the backdoor into the castle. Through an additional
immune manipulation, autologous tumor cell immunization,
we can achieve prevention of disease recurrence after surgical
resection and by analyzing induced human monoclonal
antibodies to the neoantigens, gain in site into the restriction
of diversity of the mutant clones. These findings may also
open the door for a pathway to immune prevention of cancer.
e:
mghannajr@outlook.com