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Research and Reports in Gynecology and Obstetrics | Volume 3
November 14-15, 2019 | Singapore
Obstetrics and Gynecology
4th International Conference on
Prediction of ovarian response is one of the prerequisites
for women undergoing intracytoplasmic sperm injection
(ICSI) treatment prior to the first controlled ovarian
stimulation (COS) cycle. Predictive factors may be variable
in patients pre-treated with oral contraceptives (OC) for
scheduling purposes. To evaluate antral follicle count (AFC),
anti-Mullerian hormone (AMH) and basal follicle stimulating
hormone (FSH) for predicting ovarian responses in patients
under controlled ovarian hyperstimulation randomized to
receive either oral contraceptives (OC) or no treatment (non-
OC) prior to their first controlled ovarian stimulation (COS)
cycle. One hundred infertile women randomized to receive
OC treatment or no treatment, prior to their first COS cycle;
were stimulated with Gonadotropin Releasing Hormone
(GnRH) antagonist protocol. During the early follicular
phase (day2) of the two subsequent cycles (cycle A & cycle
B) sonographic (AFC, ovarian volume) and endocrine data
(AMH, basal FSH) were recorded. Transvaginal ultrasound was
performed for all patients to monitor the ovarian response.
Total number of oocytes retrieved, and number of generated
embryos were recorded, and patients were categorized
according to retrieved oocytes as poor (oocytes <5), normal
(oocytes 5–12) or high responders (oocytes >12). AFC, AMH
and basal FSH were lower in users than in non-users of
hormonal contraception. Poor responders showed a smaller
number of oocytes retrieved and had lower AFC and AMH
but higher basal FSH levels was recorded in both groups (OC
and non-OC). The better predictive value of AMH or AFC, as a
single test or in combination will prevent cycle cancellations
due to too lowor too high ovarian response. AMH inOC group
was not affected by OC pre-treatment and is superior to other
parameters, while AFC is superior to AMH and basal FSH in
non-OC group.
Speaker Biography
Shahinaz H El-Shorbagy is currently working as the professor of Obstetrics
and Gynecology at the Tanta University, Egypt. She obtained her Fellowship
of Gynecology and Infertility from Birmingham University, UK. She is also a
consultant of IVF and Infertility and the Medical Director of Ommoma IVF
Centre, Egypt.
e:
Shahinaz H El-Shorbagy
Tanta University, Egypt
Comparison of the predictive value of antral follicle count, anti-müllerian
hormone and follicle-stimulating hormone in women following GnRH-
antagonist protocol for intracytoplasmic sperm injection
Shahinaz H El-Shorbagy, Res Rep Gynaecol Obstet, Volume:3
DOI: 10.35841/2591-7366-C3-007