gynecology-2019-keynote

3 / 9

allied
academies
Page 10
Research and Reports in Gynecology and Obstetrics | Volume 3
November 14-15, 2019 | Singapore
Obstetrics and Gynecology
4th International Conference on
To evaluate the effectiveness and safety of metformin
in improving reproductive and metabolic outcomes for
women with PCOS undergoing ovulation induction. We
searched the following databases from inception to January
2017: Cochrane Gynecology and Fertility Group Specialized
Register, CENTRAL, MEDLINE, Embase, PsycINFO and CINAHL.
Wesearchedregistersofongoingtrialsandreference listsfrom
relevant studies. We assessed the interventions metformin,
clomiphene citrate, metformin plus clomiphene citrate. We
compared these with each other, placebo or no treatment. In
total, 42 studies (4024 women) were included in the analysis.
Our updated review suggests that metformin alone may be
beneficial over placebo for live birth, although the evidence
quality was low. When metformin was compared with
clomiphene citrate, data for live birth were inconclusive, and
our findings were limited by lack of evidence. Results differed
by body mass index (BMI), emphasizing the importance
of stratifying results by BMI. An improvement in clinical
pregnancy and ovulation suggests that clomiphene citrate
remains preferable to metformin for ovulation induction in
obese women with PCOS. An improved clinical pregnancy
and ovulation rate with metformin and clomiphene citrate
versus clomiphene citrate alone suggests that combined
therapy may be useful although we do not knowwhether this
translates into increased live births. Women takingmetformin
alone or with combined therapy should be advised that there
is no evidence of increased miscarriages, but gastrointestinal
side effects are more likely.
Speaker Biography
Thomas Tang graduated from the University of Aberdeen and did most
of his specialist training in the Yorkshire region. He was awarded a
postgraduate degree of Doctor of Medicine by the University of Leeds
in 2007; his research focused on fertility care for women with Polycystic
Ovary Syndrome. He became a consultant in 2010 and joined the team
in the Regional Fertility Centre, Belfast in 2012, offering a broad range of
fertility treatments including ovulation induction and IVF/ICSI, as well as
fertility preservation. He is also interested on postgraduate education and
is currently an associate editor in the RCOG journal ‘The Obstetrician and
Gynecologist’ as well as an honorary senior lecturer in the University of
Leeds.
e:
Thomas Tang
Belfast Health and Social Care Trust, UK
Update on the use of metformin in women with PCOS
Thomas Tang, Res Rep Gynaecol Obstet, Volume:3
DOI: 10.35841/2591-7366-C3-007