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Journal of Microbiology: Current Research | Volume 2
November 01-02, 2018 | London, UK
7th EuropeanClinical Microbiology Congress
4th International Conference onOphthalmology and Eye Disorder
Joint Event
&
Insights into genetic basis of virulence in Salmonella Dublin
Manal Mohammed
University of Westminster, UK
Salmonellosis is one of the most common foodborne
diseases worldwide that causes a huge burden of morbidity
and mortality in humans. Although non-typhoidal Salmonella
servoars including Salmonella Dublin are associated primarily
with self-limiting gastrointestinal illness they have adapted
to cause invasive disease and systemic illness in humans
particularly children, elderly and immunocompromised
people. Salmonella enterica serovar Dublin is a zoonotic
infection that can be transmitted from cattle to humans
through consumption of contaminated milk and milk products.
Outbreaks of human infections by Salmonella Dublin have been
reported in several countries including high-income countries.
The genetic basis of virulence and invasiveness of Salmonella
Dublin is not well characterized. We apply next generation
sequencing and associated bioinformatics analyses tools is
characterize the invasome of Salmonella Dublin that enable
the bacteria to cause systemic illness in humans. We identified
several virulence factors that enable the bacteria to cause
invasive disease in humans however, no genomic markers were
detected that differentiate among invasive and non-invasive
isolates suggesting that host factors and immune response play
a significant role in the disease outcome. There is no vaccine
against non-typhoidal Salmonella however our understanding
of themolecular basis of virulence in invasive Salmonella Dublin
will provide insights into thedevelopment of aneffectivevaccine
through identificationof novel virulence-attenuated strainswith
a potential for use as vaccine candidates for high-risk groups.
Speaker Biography
Manal Mohammed is a lecturer in Medical Microbiology at University of Westminster,
UK. She did her PhD at University of Liverpool, UK where she studied the molecular
evolution of incurable Japanese encephalitis virus associated with high morbidity
and mortality in humans. Her research is focused on application of next generation
sequencing technologies and associated bioinformatics analyses tools in investigating
the molecular basis of virulence of non-typhoidal salmonellosis in humans and
understanding the complex dynamics of bacteria-phage interaction aiming to develop
phage therapy as an alternative to antibiotics.
e:
Manal Mohammed, Clinical Microbiology and Eye 2018, Volume 2
DOI: 10.4066/2591-8036-C1-002