Journal of Clinical Pathology and Laboratory Medicine

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Short Communication - Journal of Clinical Pathology and Laboratory Medicine (2023) Volume 5, Issue 4

Tuberculosis and therapeutics: A battle worth fighting together

Hofman James*

Department of Clinical Pathology,Radboud University, Netherlands.

*Corresponding Author:
Hofman James
Department of Clinical Pathology
Radboud University

Received:27-Jul-2023, Manuscript No. AACPLM-23-108847; Editor assigned:31-Jul-2023, PreQC No. AACPLM-23-108847(PQ); Reviewed:15-Aug-2023, QC No. AACPLM-23-108847; Revised:21-Aug-2023, Manuscript No. AACPLM-23-108847(R); Published:28-Aug-2023, DOI:10.35841/aacplm-5.4.158

Citation: James H. Tuberculosis and therapeutics: A battle worth fighting together. J Clin Path Lab Med. 2023;5(4):158


Tuberculosis is one of humanity's oldest and deadliest foes, dating back thousands of years. Despite significant progress in medical science, this infectious disease remains a global health threat, causing millions of deaths each year. While challenges persist, advances in therapeutic interventions have offered a glimmer of hope in the fight against TB. In this opinion article, we will explore the importance of continued research and collaboration in tackling this ancient scourge and the significance of therapeutics in shaping a healthier future.


Tuberculosis, Drug-resistant, Misconceptions.


Tuberculosis remains a significant public health concern worldwide, disproportionately affecting low and middle-income countries. According to the World Health Organization (WHO), approximately 10 million people fell ill with TB in 2020, and 1.4 million lost their lives to this infectious disease. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), has further complicated the efforts to control the disease. Overcoming TB's challenges necessitates a multifaceted approach, with an emphasis on therapeutic interventions. Despite some progress, the development of novel TB drugs has been slow, and treatment options for drug-resistant strains remain limited and often associated with severe side effects. The lengthy treatment duration and patient non-compliance have contributed to the spread of drug-resistant TB, emphasizing the pressing need for more effective and patient-friendly therapeutics[1].

The battle against TB requires renewed investment in research and development. It is essential to explore innovative therapeutic approaches, such as developing new drug classes, repurposing existing drugs, and investigating host-directed therapies. Research institutions, governments, and pharmaceutical companies must collaborate to accelerate the discovery and development of potent, safe, and affordable TB drugs[2].

In recent years, significant advancements have been made in identifying potential drug candidates. For instance, several new TB drugs have shown promising results in clinical trials, offering hope for more effective treatments. Additionally, advancements in diagnostic technologies and the utilization of artificial intelligence in drug development have expedited the identification of potential drug targets[3].

Tuberculosis knows no borders, making global collaboration an indispensable component in combating the disease. International partnerships are crucial for sharing knowledge, expertise, and resources to accelerate research and promote equitable access to effective therapeutics. Furthermore, collaborations between public and private sectors can foster the development of innovative funding models and incentivize the creation of new TB drugs[4].

Governments around the world should prioritize funding for TB research and ensure that resources are appropriately allocated to address the disease's multifaceted challenges. At the same time, pharmaceutical companies should consider the greater good and engage in public-private partnerships to support the development of TB therapeutics. In addition to research and therapeutic advancements, community engagement and awareness are vital aspects of TB control. Stigma and misconceptions surrounding the disease can impede early diagnosis and treatment adherence. Initiatives that promote education and public awareness can help break down barriers and facilitate earlier identification and management of TB cases[5].


Tuberculosis remains a formidable global health challenge, but the advances in therapeutic interventions provide a beacon of hope in our fight against this ancient scourge. To win this battle, we must prioritize and invest in research, foster global collaborations, and engage communities to enhance awareness and reduce stigma. By joining forces and dedicating resources to the development of innovative and patient-friendly therapeutics, we can move closer to a world where TB is no longer a deadly threat, but a vanquished foe. The fight against tuberculosis is not just a medical endeavour; it is a testament to our shared humanity and our commitment to creating a healthier and more equitable world for all.


  1. Smith GC, Pell JP. Parachute use to prevent death and major trauma related to gravitational challenge: Systematic review of randomised controlled trials.BMJ. 2003; 327(7429):1459-61.
  2. Indexed at, Google Scholar, Cross Ref

  3. Gumbo T, Lenaerts AJ, Hanna D, et al. Nonclinical models for antituberculosis drug development: A landscape analysis. J Infect Dis. 2015; 211(suppl_3):S83-95.
  4. Indexed at, Google Scholar, Cross Ref

  5. Pasipanodya J, Gumbo T. An oracle: Antituberculosis pharmacokinetics-pharmacodynamics, clinical correlation, and clinical trial simulations to predict the future.Antimicrob Agents Chemother. 2011; 55(1):24-34.
  6. Indexed at, Google Scholar, Cross Ref

  7. Ambrose PG, Bhavnani SM, Rubino CM, et al. Pharmacokinetics-pharmacodynamics of antimicrobial therapy: It's not just for mice anymore.Clin Infect Dis. 2007; 44(1):79-86.
  8. Indexed at, Google Scholar, Cross Ref

  9. Meesters K, Alemayehu T, Benou S, et al. Pharmacokinetics of antimicrobials in children with emphasis on challenges faced by low and middle income countries, a clinical review.Antibiotics. 2022; 12(1):17.
  10. Indexed at, Google Scholar, Cross Ref

Get the App