Research Article - Journal of Trauma and Critical Care (2019) Volume 3, Issue 1
The incidence of chronic pain following tibial diaphyseal fracture.
1Department of Surgery, Imperial College London and The University of Sheffield, Sheffield, UK
- *Corresponding Author:
- Francois Prinsloo
University of Sheffield Beech Hill Road
Sheffield S10 2RX
Tel: 0114 222 5522
E-mail: [email protected]
Accepted date: January 21, 2019;
Citation: Prinsloo F, Flynn C, Prime M. The incidence of chronic pain following tibial diaphyseal fracture. J Trauma Crit Care. 2019;3(1):6-11
Fracture, Chronic pain, Injury, Trauma.
Introduction: Chronic pain affects up to 40% of patients at 7 years after tibial fracture impacting on their quality of life (QoL) and ability to participate in activities of daily living. Major nerves run in close proximity to the tibia and are prone to injury during tibial fracture. Nerve injury can cause acute neuropathic pain, which responds poorly to commonly prescribed analgesics and predisposes patients to developing chronic pain. This study aims to describe the incidence and impact of pain at 6-12 months after tibial fractures. Methods: Patients admitted to a major trauma centre between 01/01/2016 – 31/12/2016 with isolated tibial fractures were identified using prospectively recorded database eTrauma. Injuries were categorized using the AO classification. Pain and Quality of Life at 6-12 months post injury were assessed using the EuroQol (EQ-5D-5L) questionnaire and the Douleur Neuropathique 4 questionnaire for neuropathic pain. Results: Forty isolated tibial fractures were identified and 20 were followed up. Pain was reported by 18 (90%) of patients. Ten (50%) reported moderate to severe pain, with median pain scores of 2.6/5. Pain scores were significantly greater following high-energy injuries however no significant links were seen between pain and other patient, injury or management factors. Conclusion: Chronic pain is common following tibial fracture and is largely under-reported. Further prospective multi-center investigation is warranted to better identify those with neuropathic pain and other risk factors for chronic pain. This could guide effective management and improve patient outcomes
Tibial diaphyseal fractures account for 4% of all fractures  and 40% of all open fractures . They are the commonest long bone fracture in the UK with an annual incidence of 16.9-22 per 100,000 patient years [3-6]. This injury is mostly seen in young men following high-energy mechanisms such as road traffic collisions (RTC) [1,7] and also in older women where, due to the onset of degenerative changes, low-energy mechanisms predominate [3,4,8].
The duration of recovery from tibial fractures is dependent on the injury severity, but frequently rehabilitation can take many months  often hindered by chronic pain . Moderate to severe pain persists in 40-78% of patients 12 months after severe tibial trauma [15-17] and has been reported as present in 40% of patients 7 years post injury . This complication can leave patients with psychological distress, impacting upon quality of life and impair ability to participate in society [18,19].
The aim of this study was to identify the incidence of chronic pain occurring 6 to 12 months post-tibial diaphyseal fracture the hypothesis being that chronic pain will be seen in this patient cohort. Secondary aims were to describe the epidemiology, morphology and acute management of such tibial diaphyseal fractures. These findings can be used to inform the feasibility of future studies.
Patients presenting to a London Major Trauma Centre between 01/01/2016-31/12/2016 with fractures of the tibial diaphysis were retrospectively identified using ‘eTrauma’ (OpenMedical, London, UK), a digital trauma management system. Cases were validated against the hospitals Electronic Health Record (Cerner Corporation, North Kansas City, USA) and submissions to the Trauma Audit and Research Network (TARN) database. Data collection was done at St Mary’s hospital 01/04/2017-30/06/2017. Patient demographic information, injury mechanism, fracture morphology, pain score, pain management in the first 24 hours and orthopaedic management were recorded from prospectively documented at the time of injury on the electronic health record. Patients were excluded for predetermined reasons shown in Figure 1. Injuries were classified using the AO classification system or GA system where appropriate. Numerical acute pain scores were converted to mild, moderate or severe for analysis, with scores of 1-3 out of 10 being mild, 4-6 moderate and 7-10 severe pain.
Patients with isolated tibial diaphyseal fractures who presented between 01/05/2016 - 30/10/2016 (6 to 12 months post-injury) were identified and contacted by telephone. In order to minimize selection bias, patients were called a total of four times before exclusion ensuring at least one attempt in the morning between 9:00-12:00, once in the afternoon 12:01-17:00 and once in the evening 17:00- 19:00. Ethical approval was gained prior to this and verbal consent was sought from each patient to proceed.
Participants were asked to complete the five level EQ-5D-5L to identify the presence of pain and quality of life (QoL). A time trade-off score (TTO) was calculated using EQ-5D-5L, where 1 is full QoL and 0 equivalent to death(20). Patients were also asked to assess their QoL using the EQVAS score (0-100). Questions were subsequently asked from the Douleur Neuropathique 4 (DN4) scoring system to elicit symptoms of neuropathic pain although a complete score could not be gained as patients did not receive physical examination [20,21]. Functional outcomes scores were collected at 6-12 months postinjury using the EQ-5D-5L. To minimize recall bias, questions were asked exactly as stated on official questionnaires.
Statistical analysis was performed using SPSS (version 184.108.40.206, IBM, Chicago, USA). Data was tested for normality using the Shapiro Wilk test. Kruskal-Wallis and Mann-Whitney U tests were used compare the impacts of patient demographic and injury morphology on levels of chronic pain. Spearman’s rank correlation coefficient was used to assess associations between EQ-5D outcomes and QoL.
This study identified 130 tibial diaphyseal fractures, 93 (71.5%) of whom were male. The median patient age was 42 years (IQR 31.75-54.25). Men were typically younger, with a median age of 39, compared with 48.5 in women (Figure 1).
High-energy trauma was responsible for 60.8% of all injuries and made up 66.7% of all male and 44.1% of all female injuries (Figure 2) (Table 1).
Table 1. Table showing the breakdown of mechanisms of TF in the overall population.
|Energy||Mechanism of injury||Male||Female||Total proportion of injuries|
|High-energy||RTC – Pedestrian||21||12||25%|
|RTC – Motorbike||22||0||17%|
|RTC – Cyclist||2||0||1%|
|RTC – Auto||1||1||1%|
|Fall from over 2 m||13||1||11%|
|Fall from under 2 m||15||13||22%|
Isolated injuries accounted for 74.6% of all fractures. AO type A made up 46.9%, type B 32.3% and type C 20.8% as seen in Figure 3.
Open fractures made up 43%. GA and AO classifications of severity distribution are shown in Figure 4. High-energy trauma caused 75.4% of open fractures.
Acute pain and management
Pain levels in the first 24 hours as recorded in patient notes were ‘no pain’ in 1 (0.8%), mild in 4 (3.1%), moderate in 28 (21.5%) or severe in 53 (40.8%). Pain scores were not recorded in patient notes for 44 patients (33.8%). In the first 24 hours, 90% received paracetamol with an opioid. Additional analgesia with NSAIDs, ketamine or regional blocks using levobupivacaine was given to 12 (9.3%). Neuromodulators were prescribed to 27 patients (20.8%); 8 patients (29.6%) of this group received them within 24 hours with a further patients 9 (33.3%) receiving them within a week and 8 (29.6%) between 1-3 weeks. The remaining 2 patients (6.9%) waited over 3 weeks. The median length of neuromodulator prescription was 26 days (IQR 10-154).
Pain at follow up
Mean follow-up time was 305 days (IQR 244.25-344.25) with a median pain score of 2.5 out of 5 (IQR 2-3). Persisting pain was reported by 18 patients (90%) and was graded as moderate to extreme in 10 patients (50%), see Figure 5. Median levels of pain according to EQ5D results were 3/5 in those who sustained high-energy fractures compared with 2/5 for low-energy fractures (P=0.016). No other patient injury or management related factors significantly impacted on pain at 6-12 months. Features of neuropathic pain were present at follow-up in 7 respondents (35%). Median pain intensity was 3/5 (IQR 2) in those with neuropathic pain on follow-up according to DN4 compared to 2/5 (IQR 1) in those who did not. Of those with suspected neuropathic pain according to the DN4, 57% had received neuromodulators. There was no documentation about features of acute neuropathic pain in any patient. Twenty patients did not respond to follow-up; 9 did not answer to any of the calls made according to study design; 9 were unwilling to participate; 2 had the wrong contact details recorded.
Quality of life
EQ-5D responses are shown in Figure 6. Self-reported QoL in this population was perceived as 60.4% of a full QoL. Calculated QoL was 0.55, with 1 being full health as calculated using EQ- 5D TTO scores.
This study found that 90% of patients report pain persisting 6-12 months after their initial injury, with over half reporting moderate-extreme pain and a third displaying features of neuropathic pain. This is higher than previously reported.
Pain and management
As in previous literature, acute pain was almost universal for those with pain information recorded at the time of injury. Pain was documented as severe in over half of these. Pain assessment was not recorded in a third of cases, which is inadequate, but in keeping with previous research showing that inpatient pain is both poorly assessed and managed . Acute pain is typically nociceptive, but acute neuropathic pain may also occur following damage to peripheral nerves [23,24]. These major nerves of the lower limb run in close proximity to the tibia making them at particularly high risk of stretch or compression injury and prone to the development of acute neuropathic pain. This results in spontaneous and provoked pain impulses as well as deficits in normal sensation .
Poorly controlled acute pain is a risk factor for the development of chronic pain  as illustrated by the LEAP study; here acute pain intensity at 3 months following severe tibial fracture was the strongest predictor for pain at 7 years .
Chronic pain may occur after tibial fractures for a number of reasons. Cellular and molecular changes at the site of neural injury and in surrounding nerves, including clustering of sodium gated ion channels, expression of α-adrenoreceptors, infiltration of inflammatory cells and cytokines and an up regulation of pain transmission receptors leading to peripheral sensitisation [27-29]. Persistent and ectopic action potentials generated from poorly controlled acute pain can result in persistent maladaptive changes in peripheral nerves and the dorsal horn of the spinal cord . Frequent stimulation of the dorsal horn can lead to increased expression and activation of receptors for excitatory neurotransmitters and apoptotic loss of inhibitory GABA neurones [30,31]. Bio-psychosocial variables also contribute to the development of chronic pain, including social group, educational status, low self-efficacy and untreated depression [18,32-36].
Pain persisted at 6-12 months after injury in 90% of this cohort with half of all patients reporting moderate to extreme pain. This is a greater incidence than previously described and illustrates the extent of the problem of chronic pain following tibial diaphysis fractures. Levels of chronic pain were not found to be affected by surgical management modality, gender, or injury severity. There was however a strong positive correlation between those who sustained high-energy injuries and levels of chronic pain.
This is possibly due to the mechanical strain on peripheral nerves being higher in high-energy injuries thus increasing the likelihood of peripheral nerve damage. This study did not look at the role of fracture union on chronic pain; however this is an important factor to be addresses in future research. A median pain score of 2.5/5 was found which is similar to Rivara et al.’s finding of pain scores of 5.5/10 in patients 1 year after major trauma . Rivara’s study focused on more severe Gustillo & Anderson 3a-3b fractures, whilst our study has noted similar pain scores in less severely injured people. Additionally we found that a third of patients had features of neuropathic pain (according to DN4 diagnostic criteria) at late follow-up and only 50% of these people had been prescribed neuromodulators, highlighting under-recognition of the problem. Features of acute neuropathic pain were not documented in any patients records.
QoL is greatly reduced in the chronic pain population according to both calculated and self-reported QoL.
Acute pain management of tibial fractures usually involves a combination of paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. This management was seen in 93% of patients. Neuropathic pain is poorly responsive to these drugs and therefore interest has begun to grow in the use of more advanced treatments such as local anaesthetic nerve blocks, ketamine and neuromodulators such as gabapentin and pregabalin. The neuromodulators are antagonists at the α2δ subunit of presynaptic calcium channels, whose expression is increased in the dorsal horn of patients with chronic pain, and have been shown to be effective for acute neuropathic pain and reduce the risk of chronicity [23,30,37-44]. Thus, better identification of patients who would benefit from such therapy could lead to an improvement in rates of chronic pain in these patients.
Injury mechanisms and morphology
Whilst the higher incidence in male patients was concordant with previous estimates [1,3,4], the average age of patients was higher and there were fewer sports related injuries than previously reported [3,4]. This may be due, in part, to the exclusion of paediatric cases.
High-energy causes, such as RTC’s and falls from over 2 metres, predominated. These injuries were almost exclusively sustained by men, whilst women were more likely to suffer low-energy injuries. The high-energy injury mechanisms led to a higher incidence of more serious AO type B and C fractures than previously demonstrated [1,3]. Moreover, 43% of fractures were open, compared to 23.5% found by Court-Brown and Caesar . These findings are most likely due to the study taking place in a single urban hospital designated as a major trauma centre, where the majority of tibial fractures are caused by RTC’s and occupational trauma.
As a single centre study in an urban major trauma centre, some results pertaining to injury cause, injury severity and intervention may only be generalizable to similar centres. Little previous work has focussed on pain after tibial injury meaning it is difficult to adequately power this study to detect the significance of chronic pain levels at 6-12 months post injury. Follow-up rates were relatively low, and the patients who declined to participate could represent a population that affected the studies findings in either direction. Due to the nature of trauma, EQ-5D data could not be collected prior to the injury and so it is difficult to see the true effect tibial fracture has on these patients.
Pain is a significant problem after tibial diaphysis fractures. It is poorly assessed in the acute phase and moderate-severe pain persists in half of patients surveyed at 6-12 months post injury, with observable effects on individuals’ quality of life. Education programs highlighting the importance of acute pain management in potential prevention of chronic pain must be developed. Additionally, accurate assessment and documentation of pain is crucial to both improve patient care and facilitate research on the putative link between acute and chronic pain. Further multicenter observational work is need to accurately identify the presence of acute nerve dysfunction, acute and chronic nociceptive and neuropathic pain features and their sequelae in this patient group.
Conflict of Interest and Funding
There are no conflicts of interest or funding to declare. Project completed as part of a BSc at Imperial College, London.
- Court-Brown CM, McBirnie J, Tornetta P. The epidemiology of tibial fractures. J Bone Joint Surg Br. 1995;77(3):417-21.
- Court-Brown CM, Rimmer S, Prakash U, et al. The epidemiology of open long bone fractures. Injury. 1998;29(7):529-34.
- Larsen P, Elsoe R, Hansen SH, et al. Incidence and epidemiology of tibial shaft fractures. Injury. 2015;46(4):746-50.
- Court-Brown CM, Bugler KE, Clement ND, et al. The epidemiology of open fractures in adults. A 15-year review. Injury. 2012;43(6):891-7.
- Weiss RJ, Montgomery SM, Ehlin A, et al. Decreasing incidence of tibial shaft fractures between 1998 and 2004: information based on 10,627 Swedish inpatients. Acta Orthop. 2008;79(4):526-533.
- Court-Brown CM, Caesar B. Epidemiology of adult fractures: A review. Injury. 2006;37:691-7.
- Howard M, Court-Brown CM. Epidemiology and management of open fractures of the lower limb. Br J Hosp Med. 1997;57(11):582-587.
- Singer BR, McLauchlan GJ, Robinson CM, et al. Epidemiology of fractures in 15,000 adults: the influence of age and gender. J Bone Joint Surg Br. 1998;80(2):243-8.
- Müller ME. Müller AO. Classification of Fractures-Long Bones. AO Foundation. 1987;1-7.
- Gustilo R, Anderson JT. Prevention of infection in the treatment of one thousand and twenty five open fractures of long bones: retrospective and prospective analyses. J Bone Jt Surg - Ser A. 1976;58(4):453-458.
- https://www.boa.ac.uk/wp-content/uploads/2014/05/BOAST-4-The- Management-of-Sever-Open-Lower-Limb-Fractures.pdf
- Shauver MS, Aravind MS, Chung KC. A qualitative study of recovery from type III-B and III-C tibial fractures. Ann Plast Surg. 2011;66(1):73-9.
- Perkins ZB, De’Ath HD, Sharp G, et al. Factors affecting outcome after traumatic limb amputation. Br J Surgery. 2012;99:75-86.
- Dickson DR, Moulder E, Hadland Y, et al. Grade 3 open tibial shaft fractures treated with a circular frame, functional outcome and systematic review of literature. Injury. 2015;46(4):751-758.
- Hayes C, Browne S, Lantry G, et al. Neuropathic pain in the acute pain service: A prospective survey. Acute Pain. 2002;4(2):45-8.
- Khan JS, Devereaux PJ, Lemanach Y, et al. Patient coping and expectations about recovery predict the development of chronic post-surgical pain after traumatic tibial fracture repair. Br J Anaesth. 2016;117(3):365-70.
- Castillo RC, MacKenzie EJ, Wegener ST, et al. Prevalence of chronic pain seven years following limb threatening lower extremity trauma. Pain. 2006;124(3):321-9.
- McCarthy ML, MacKenzie EJ, Edwin D, et al. Psychological distress associated with severe lower-limb injury. J Bone Joint Surg Am. 2003;85(9):1689-97.
- Devlin NJ, Shah KK, Feng Y, et al. Valuing health-related quality of life: An EQ-5D-5L value set for England. Health Econ. 2017.
- Padua L, Briani C, Truini A, et al. Consistence and discrepancy of neuropathic pain screening tools DN4 and ID-Pain. Neurol Sci. 2013;34(3):373-7.
- Kemp HI, Bantel C, Gordon F, et al. Pain assessment in intensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom. Anaesthesia. 2017.
- Clarke H, Woodhouse LJ, Kennedy D, et al. Strategies aimed at preventing chronic post-surgical pain: Comprehensive perioperative pain management after total joint replacement surgery. Physiother Canada. 2011;63(3):289-304.
- Merskey H, Bogduk N. IASP task force on taxonomy part III: pain terms, A current list with definitions and notes on usage. IASP Task Force Taxon. 1994;209-14.
- Schaefer C, Sadosky A, Mann R, et al. Pain severity and the economic burden of neuropathic pain in the United States: BEAT Neuropathic Pain Observational Study. Clin Outcomes Res. 2014;6:483-96.
- Costigan M, Scholz J, Woolf CJ. Neuropathic pain: A maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32(1):1-32.
- Baron R. Mechanisms of disease: neuropathic pain - a clinical perspective. Nat Clin Pract Neurol. 2006;2(2):95-106.
- Baron R, Levine JD, Fields HL. Cauusalgia and reflex sympathetic dystrophy: Does the sympathetic nervous system contribute to the generation of pain. Muscle Nerve. 1999;22:678-95.
- Sommer C. Painful neuropathies. Curr Opin Neurol. 2003;16(5):623-8.
- Dworkin RH, Corbin AE, Young JP, et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurol. 2003;60(8):1274-83.
- Wasner G, Kleinert A, Binder A, et al. Postherpetic neuralgia: Topical lidocaine is effective in nociceptor-deprived skin. J Neurol. 2005;252(6):677-86.
- Portenoy RK, Ugarte C, Fuller I, et al. Population-based survey of pain in the united states: differences among white, african american, and hispanic subjects. J Pain. 2004;5:317-28.
- Turner JA, Jensen MP, Warms CA, et al. Catastrophizing is associated with pain intensity, psychological distress, and pain-related disability among individuals with chronic pain after spinal cord injury. Pain. 2002;98:127-34.
- Brittany NR, Sobia K, McCartney C, et al. Systematic review of persistent pain and psychological outcomes following traumatic musculoskeletal injury. J Pain Res. 2013;6:39-51.
- Rivara FP, Mackenzie EJ, Jurkovich GJ, et al. Prevalence of pain in patients 1 year after major trauma. Arch Surg. 2008;143(3):282-87.
- Schug SA, Palmer GM, Scott DA, et al. Acute pain management: scientific evidence, fourth edition, 2015. Med J Aust. 2016;204(8):315-17.
- Mathiesen O, Jacobsen LS, Holm HE, et al. Pregabalin and dexamethasone for postoperative pain control: A randomized controlled study in hip arthroplasty. Br J Anaesth. 2008;101(4):535-41.
- McCartney CJL, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg. 2004;98(5):1385-1400.
- Cao Y, Wang H, Chiang CY, et al. Pregabalin suppresses nociceptive behavior and central sensitization in a rat trigeminal neuropathic pain model. J Pain. 2013;14(2):193-204.
- Katz J, Clarke H, Seltzer Z. Preventive analgesia: Quo vadimus? Anesth Analg. 2011;113:1242-53.
- Saldaña MT, Navarro A, Pérez C, et al. Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: Evidence from medical practice in primary care settings. Rheumatol Int. 2010;30(8):1005-15.
- Buvanendran A, Kroin JS, Della VCJ, et al. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: A prospective, randomized, controlled trial. Anesth Analg. 2010;110(1):199-207.
- Stacey BR, Dworkin RH, Murphy K, et al. Pregabalin in the treatment of refractory neuropathic pain: Results of a 15-month open-label trial. Pain Med. 2008;9(8):1202-08.
- Gordh TE, Stubhaug A, Jensen TS, et al. Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study. Pain. 2008;138(2):255-66.