Gynecology and Reproductive Endocrinology

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Perspective - Gynecology and Reproductive Endocrinology (2023) Volume 7, Issue 6

Spontaneous ovarian hyper stimulation syndrome in young women with partial hydatidiform mole

Barbori Satyai *

Department of Obstetrics, Gynecology, Perinatology and Reproductology, Sechenov University, Moscow, Russia

*Corresponding Author:
Barbori Satyai
Department of Obstetrics,Gynecology, Perinatology and Reproductology
Sechenov University,
Moscow, Russia

Received: 05-Nov-2023, Manuscript No. AAGGS-23-120313; Editor assigned: 06-Nov2023, PreQC No. AAGGS-23-120313(PQ); Reviewed:21-Nov-2023, QC No. AAGGS-23-120313; Revised:27-Nov-2023, Manuscript No. AAGGS-23-120313(R); Published: 30-Nov-2023, DOI: 10.35841/2591-7994-7.6.180

Citation: Satyai B. Spontaneous ovarian hyper stimulation syndrome in young women with partial hydatidiform mole. Gynecol Reprod Endocrinol.2023;7(6):180

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Ovarian Hyper Stimulation Syndrome (OHSS) is a medical condition that can occur in women undergoing fertility treatments, particularly those involving the use of medications to stimulate the ovaries. This syndrome results from an exaggerated response of the ovaries to the hormonal stimulation, leading to a cascade of symptoms and potential complications. OHSS is most commonly associated with fertility treatments that involve the administration of hormones such as Human Chorionic Gonadotropin (HCG) and Follicle-Stimulating Hormone (FSH). These medications stimulate the ovaries to produce multiple eggs, increasing the chances of successful fertilization and pregnancy [1].


The hormonal stimulation can cause the ovaries to become enlarged and cystic, leading to the accumulation of fluid in the abdominal cavity and other tissues. The release of vasoactive substances in response to the hormonal changes contributes to the increased permeability of blood vessels, resulting in fluid leakage and swelling. Symptoms of OHSS can range from mild to severe and may include abdominal bloating and discomfort, nausea, vomiting, and respiratory distress.

Severe cases can lead to fluid accumulation in the abdominal and chest cavities, electrolyte imbalances, and, rarely, thromboembolic events. Spontaneous Ovarian Hyper Stimulation Syndrome (OHSS) is a condition characterized by an exaggerated response of the ovaries to hormonal stimulation. While it is commonly associated with fertility treatments, its occurrence in the absence of such interventions is a rare and intriguing phenomenon [2]. This case report delves into the unique scenario of young women presenting with both Spontaneous OHSS and a Partial Hydatidiform Mole, shedding light on the clinical intricacies and challenges associated with this combination.

Partial Hydatidiform Mole (PHM) is a rare form of gestational trophoblastic disease, involving abnormal fetal development. Meanwhile, OHSS typically occurs as a complication of ovarian stimulation in assisted reproductive technologies. The coexistence of these two conditions in young women without any fertility treatment poses a clinical puzzle that warrants thorough investigation [3].

Case Presentation

The cases under discussion involve young women who presented with symptoms of OHSS in the absence of any fertility treatments. Upon further examination, a concurrent diagnosis of Partial Hydatidiform Mole was established. This unexpected association raises questions about the underlying mechanisms and potential links between these two distinct conditions.

Spontaneous OHSS is characterized by enlarged ovaries, fluid shifts into the abdominal cavity, and a range of symptoms including abdominal distension, nausea, and respiratory distress. The addition of a Partial Hydatidiform Mole introduces complexities related to abnormal placental development, which may exacerbate the symptoms and complicate management strategies [4].

The exact mechanisms linking Spontaneous OHSS and Partial Hydatidiform Mole remain elusive. Some hypotheses suggest that the trophoblastic abnormalities in the mole may lead to an increased production of Human Chorionic Gonadotropin (HCG), triggering ovarian hyper stimulation. Alternatively, shared predisposing factors or genetic susceptibilities may contribute to the co-occurrence of these conditions.

Diagnosing Spontaneous OHSS in the absence of fertility treatments can be challenging, as healthcare providers may not initially consider this possibility. Moreover, the concurrent presence of a Partial Hydatidiform Mole complicates the diagnostic process, requiring a comprehensive approach involving imaging studies, hormone assays, and histopathologic examination. The management of Spontaneous OHSS in the context of Partial Hydatidiform Mole involves a multidisciplinary approach. Careful monitoring of symptoms, supportive measures to address fluid shifts, and consideration of the gestational trophoblastic disease in treatment planning are crucial aspects. The potential implications for future fertility and long-term health must also be taken into account [5-10].


The coexistence of Spontaneous OHSS and Partial Hydatidiform Mole in young women, without the influence of fertility treatments, represents a unique and poorly understood clinical entity. Further research is warranted to unravel the underlying mechanisms, risk factors, and optimal management strategies for this rare combination of conditions. This case report contributes to the growing body of knowledge in reproductive medicine and underscores the importance of considering diverse diagnostic possibilities in the face of complex clinical presentations.


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