Commentary - Journal of Pharmaceutical Chemistry & Chemical Science (2023) Volume 7, Issue 3
Revolutionizing Synthesis: The Role of Mechanochemistry in Drug Discovery
Evelina Laurencin *
Department of Science and Technology,State University of Ceara Fortaleza, Brazil
- *Corresponding Author:
- Evelina Laurencin
Department of Science and Technology
State University of Ceara
Received:29-May-2023, Manuscript No. AACCR-23-94618; Editor assigned:01-Jun-2023, PreQC No. AACCR-23-94618(PQ); Reviewed:15-Jun-2023, QC No. AACCR-23-94618; Revised:20-Jun-2023, Manuscript No. AACCR-23-94618(R); Published:27-Jun-2023, DOI:10.35841/aapccs-7.3.147
Citation: Laurencin E. Revolutionizing synthesis: The role of mechanochemistry in drug discovery. J Pharm Chem Chem Sci 2023;7(3):147
The field of drug discovery is constantly evolving, driven by the need for innovative and efficient approaches to develop new pharmaceutical agents. Traditional methods of synthesis often rely on lengthy reaction times, the use of hazardous solvents, and multiple purification steps. However, a rapidly emerging technique, known as mechanochemistry, is revolutionizing the way drugs are synthesized. By harnessing mechanical force to drive chemical reactions, mechanochemistry offers significant advantages in terms of efficiency, sustainability, and the ability to access previously inaccessible molecular structures. This article explores the role of mechanochemistry in drug discovery and its potential to reshape the pharmaceutical industry .
Mechanochemistry has the power to significantly enhance the efficiency and speed of drug synthesis. Traditional methods involve the use of solvents to dissolve reactants, followed by heating or cooling to facilitate reactions. In contrast, mechanochemical reactions take place in the solid state, eliminating the need for solvents and enabling direct interaction between reactants. This solvent-free environment not only minimizes waste but also accelerates reaction rates, often leading to shorter reaction times. Mechanochemistry enables the synthesis of complex drug molecules in a fraction of the time compared to traditional methods, making the drug discovery process more efficient and cost-effective .
One of the most promising aspects of mechanochemistry is its ability to access new chemical space that was previously challenging or even impossible to explore. Mechanical force, applied through techniques such as ball milling or grinding, can induce unique reactivity and drive reactions that are otherwise unattainable using conventional approaches. Mechanochemistry allows for the formation of novel chemical bonds, opening up avenues for the synthesis of unprecedented drug scaffolds and the modification of existing drug molecules. This expanded chemical space offers drug discovery scientists a wealth of new possibilities to explore, potentially leading to the discovery of breakthrough therapeutics .
In an era where sustainability is a paramount concern, mechanochemistry shines as a green and sustainable approach to drug synthesis. By eliminating the need for large volumes of solvents and reducing waste production, mechanochemistry significantly reduces the environmental impact associated with drug manufacturing. The technique promotes the principles of green chemistry by minimizing the use of hazardous chemicals and maximizing atom economy. Mechanochemical reactions can be performed on a small scale, reducing the consumption of resources and energy required for large-scale synthesis. This environmentally friendly aspect of mechanochemistry aligns with the growing demand for sustainable practices in the pharmaceutical industry .
Drug discovery often faces synthetic challenges, such as the synthesis of highly crystalline substances or the formation of complex stereoisomers. Mechanochemistry offers unique solutions to these challenges. By subjecting materials to intense mechanical forces, mechanochemical reactions can break down crystalline structures, facilitating reactions that would be otherwise difficult or impossible to achieve. Furthermore, the precise control over the application of force allows for selective reactions, enabling the synthesis of specific stereoisomers with high purity. Mechanochemistry provides a powerful toolkit for overcoming synthetic obstacles and expanding the possibilities of drug discovery .
Mechanochemistry has emerged as a transformative approach in drug discovery, revolutionizing synthesis methodologies and opening new horizons for pharmaceutical research. By enhancing efficiency, accessing new chemical space, promoting sustainability, and overcoming synthetic challenges, mechanochemistry offers tremendous potential in accelerating the development of new drugs. As the field continues to advance, it is anticipated that mechanochemistry will become an indispensable tool in the drug discovery process, contributing to the development of safer, more effective, and more environmentally friendly pharmaceuticals..
- Jones W, Eddleston MD Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials. Faraday Discuss. 2014;170:9-34.
- Sarmah KK, Nath N, Rao DR, et al. Mechanochemical synthesis of drug-drug and drug-nutraceutical multicomponent solids of olanzapine. CrystEngComm. 2020;22(6):1120-30.
- Saikia B, Seidel-Morgenstern A, Lorenz H. Role of mechanochemistry in solid form selection and identification of the drug praziquantel. Cryst. Growth Des. 2021;21(10):5854-61.
- Pe?rez-Venegas M, Juaristi E. Mechanochemical and mechanoenzymatic synthesis of pharmacologically active compounds: A green perspective. ACS Sustain Chem Eng. 2020;8(24):8881-93.
- Anastasaki A, Nikolaou V, Nurumbetov G, et al. Mediated living radical polymerization: A versatile tool for materials synthesis. Chem Rev. 2016;116(3):835-77.