Short Communication - Journal of Pulmonology and Clinical Research (2021) Volume 4, Issue 6
Pneumonia with diabetes mellitus: The impact of systemic steroids and the time to first dose of antibioticsCommunity-Acquired Pneumonia (CAP) is the leading cause of infection related hospitalization and a major cause of morbidity and mortality in developing countries. CAP associated mortality in hospitalized patient's ranges from 8% to14% and up to 37% in patients admitted to the Intensive Care Unit (ICU). Several factors including age, septic shock, confusion and multipolar pneumonia have been associated with increased mortality. Validated scores, such as CURB-65 and Pneumonia Severity Index (PSI), are commonly used to predict mortality. In addition, patients with Diabetes Mellitus (DM) are at an increased risk of developing infections and complications with CAP being the most common. Studies have shown that pre-existing diabetes was associated with a higher risk of death following CAP. Factors associated with increased mortality in these patients included multipolar infiltrates, comorbidities, age, bacteremia, septic shock, infection with Gram-negative organisms and hyperglycemia. However, previous studies did not assess the impact of time from triage to administration of first dose of appropriate antibiotics in CAP complication rates LOS or mortality. Finally, clinical characteristics and outcomes of hospitalized diabetics with moderate-severe CAP are unknown. In previous work, we found that a delay in administration of first dose antibiotics in this patient population was associated with increased in-hospital mortality. However, we did not include all degrees of severity nor evaluate other outcomes. The primary objective of this study was to describe the clinical characteristics and risk factors for moderate-severe CAP in hospitalized patients with DM including outcomes such as development of complications, LOS and in-hospital mortality.
Visit for more related articles at Journal of Pulmonology and Clinical Research