Journal of Dermatology Research and Skin Care

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Commentary - Journal of Dermatology Research and Skin Care (2025) Volume 9, Issue 3

Patient Experience with Photodynamic Therapy: What to Expect During and After

Saren Loma*

Department of Science Technology, University of Minho, Portugal

*Corresponding Author:
Saren Loma
Department of Science Technology, University of Minho, Portugal
E-mail: soren@2c2t.uminho.pt

Received: 03-Sep -2025, Manuscript No. AADRSC-25-167963; Editor assigned: 04-Sep-2025, PreQC No. AADRSC-25-167963 (PQ); Reviewed:17-Sep-2025, QC No. AADRSC-25-167963; Revised:22-Sep-2025, Manuscript No. AADRSC-25-167963(R); Published:27-Sep-2025, DOI:10.35841/aadrsc-9.3.273

Citation: Loma S. Customized resurfacing: How skin type and concerns influence treatment plans. Dermatol Res Skin Care. 2025; 9(3):273

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Introduction

Photodynamic Therapy (PDT) is a minimally invasive treatment that combines light-sensitive drugs (photosensitizers) with a specific wavelength of light to destroy targeted abnormal or cancerous cells. PDT is widely used in dermatology, oncology, and ophthalmology, particularly for conditions like actinic keratosis, basal cell carcinoma, and acne. This article offers a detailed look into what patients can expect before, during, and after a PDT session, including preparation, the treatment experience, potential side effects, and recovery tips.[1].

Photodynamic Therapy involves three key components: a photosensitizing agent, a specific light source, and tissue oxygen. When the photosensitizer is activated by the light, it produces reactive oxygen species (ROS) that selectively damage and kill abnormal cells. Its targeted mechanism allows for minimal damage to surrounding healthy tissues. PDT has gained popularity due to its non-surgical nature, especially among patients looking for low-downtime, outpatient treatments [2].

Before undergoing PDT, patients usually meet with a dermatologist or oncologist for evaluation. A thorough history and skin examination are conducted to assess suitability for the procedure. In dermatological applications, a photosensitizer such as aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) is applied topically to the target area. The drug is left on the skin for 1–3 hours to allow for adequate absorption into the abnormal cells. Once the incubation period is complete, the treated area is exposed to a light source typically blue or red LED light, depending on the depth of the condition being treated. [3].

Some patients describe the sensation as a strong sunburn or pins and needles. Topical anesthetics or cooling devices (fans, cold air) are often used to improve comfort during the procedure. Post-treatment effects can vary based on the condition treated, the body area, and individual skin sensitivity. Common immediate effects. Patients are advised to avoid sun exposure and bright indoor light for at least 48 hours after treatment, as the skin remains photosensitive. Patients may be instructed to apply antibiotic ointments, moisturizers, and gentle cleansers during this period. Full recovery and visible improvement are generally seen within 1 to 2 weeks [4].

PDT is highly effective in reducing pre-cancerous lesions and improving skin texture, especially when repeated treatments are performed. For acne, patients often see reduced oiliness, fewer breakouts, and smoother skin. A follow-up visit is usually scheduled within 1–2 weeks to evaluate treatment response. Some conditions may require multiple sessions spaced a few weeks apart for optimal results. Patients with porphyria or lupus should avoid PDT due to increased photosensitivity. Studies have shown that most patients report high satisfaction rates, especially when prepared with realistic expectations. Those treated for acne or actinic keratosis particularly appreciate the non-invasive nature and cosmetic benefits of PDT, such as improved skin tone and clarity.[5].

Conclusion

Photodynamic Therapy is a safe, targeted, and effective treatment for a variety of dermatological and oncological conditions. Understanding what to expect before, during, and after PDT helps patients feel more comfortable and prepared, improving both outcomes and satisfaction. With proper guidance and care, PDT offers a promising solution with minimal downtime and long-term benefits.

References

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