Journal of Oral Medicine and Surgery

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Short Communication - Journal of Oral Medicine and Surgery (2023) Volume 6, Issue 4

Odontogenic tumors: Understanding the pathogenesis and clinical features.

Andrea Franco*

Academic Unit of Oral and Maxillofacial Medicine and Pathology, University of Sheffield, UK

*Corresponding Author:
Andrea Franco
Academic Unit of Oral and Maxillofacial Medicine and Pathology
University of Sheffield, UK
E-mail: Franco908@suk

Received: 21-Jun-2023, Manuscript No. AAOMT-23-105116; Editor assigned: 24-Jun-2023, PreQC No. AAOMT-23-105116(PQ); Reviewed: 07-Jul-2023, QC No. AAOMT-23-105116; Revised: 13-Jul-2023, Manuscript No. AAOMT-23-105116(R); Published: 18-Jul-2023, DOI: 10.35841/aaomt - 6.4.153

Citation: Franco A. Odontogenic tumors: Understanding the pathogenesis and clinical features. J Oral Med Surg. 2023;6(4):153

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Odontogenic tumors are a diverse group of neoplasms that originate from the tissues associated with tooth development. These tumors can arise from various components of the toothforming apparatus, including the epithelial, mesenchymal, and mixed components. Understanding the pathogenesis and clinical features of odontogenic tumors is essential for their accurate diagnosis and appropriate management [1].


The pathogenesis of odontogenic tumors is multifactorial and involves complex interactions between genetic, environmental, and developmental factors. Several theories have been proposed to explain the origin of odontogenic tumors, including the epithelial remnants theory, the cell rests of Malassez theory, and the odontogenic remnants theory. The epithelial remnants theory suggests that odontogenic tumors arise from remnants of the dental lamina or the enamel organ, which are remnants of the tooth development process. These remnants can undergo neoplastic transformation, leading to the formation of odontogenic tumors.

The cell rests of Malassez theory proposes that odontogenic tumors develop from remnants of Hertwig's epithelial root sheath, which are remnants of the root formation process. These remnants can proliferate and give rise to odontogenic tumors. The odontogenic remnants theory suggests that odontogenic tumors originate from remnants of odontogenic tissues that are left behind during tooth development. These remnants can undergo abnormal growth and differentiation, leading to the development of odontogenic tumors [2].

Clinical Features

Odontogenic tumors can manifest with a wide range of clinical features, including variations in size, location, radiographic appearance, and histopathological characteristics. The clinical presentation of odontogenic tumors can vary from asymptomatic incidental findings to locally aggressive lesions with significant morbidity. The clinical features of odontogenic tumors depend on various factors, including the specific type of tumor, its location within the oral cavity, and the stage of tumor development. Some common clinical features associated with odontogenic tumors include:

Swelling and/or pain: Odontogenic tumors can cause localized swelling and discomfort in the affected area. The size and location of the tumor can determine the extent and severity of the swelling and pain.

Changes in occlusion: Tumors located in the jawbones can cause changes in the alignment of teeth, leading to malocclusion or difficulty in biting and chewing.

Bone expansion: Larger odontogenic tumors can cause bone expansion, leading to visible changes in the contour of the affected area.

Tooth mobility or displacement: Tumors located near teeth can cause tooth mobility or displacement due to the destruction of supporting structures.

Ulceration or mucosal changes: Some odontogenic tumors can cause ulceration or changes in the overlying oral mucosa, leading to persistent non-healing ulcers or abnormal pigmentation [3].


The diagnosis of odontogenic tumors requires a combination of clinical, radiographic, and histopathological evaluations. A thorough clinical examination, including detailed medical and dental history, assessment of clinical features, and palpation of the affected area, is essential for the initial evaluation.

Radiographic imaging, such as panoramic radiographs, cone-beam computed tomography (CBCT), or intraoral radiographs, is often necessary to assess the extent, size, and internal characteristics of the tumor. Radiographic findings can provide valuable information about the location of the tumor, its relationship with adjacent structures, and the presence of associated changes in the surrounding bone.

Histopathological examination of a tissue sample obtained through biopsy is the gold standard for confirming the diagnosis of odontogenic tumors. Histopathological evaluation helps determine the specific type of tumor, its biological behavior, and the presence of any malignant transformation [4].


The management of odontogenic tumors depends on various factors, including the type, size, location, and aggressiveness of the tumor, as well as the patient's overall health and preferences. Treatment options may include surgical excision, enucleation, curettage, or a combination of these approaches. Benign odontogenic tumors are typically treated with conservative surgical approaches aimed at complete removal of the tumor while preserving the surrounding healthy tissues. Malignant odontogenic tumors may require more extensive surgical procedures, including resection of involved bone, neck dissection, and adjuvant therapies such as radiation and chemotherapy [5].


Odontogenic tumors are a diverse group of neoplasms that arise from tooth-forming tissues. Understanding their pathogenesis and recognizing their clinical features are crucial for accurate diagnosis and appropriate management. Dentists, oral and maxillofacial surgeons, and pathologists play a vital role in the identification, evaluation, and treatment of odontogenic tumors. By staying informed about the latest advancements in the field and maintaining a multidisciplinary approach, healthcare professionals can provide optimal care to patients with odontogenic tumors and improve their overall outcomes.


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