Journal of Neuroinformatics and Neuroimaging

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Opinion Article - Journal of Neuroinformatics and Neuroimaging (2023) Volume 8, Issue 3

Neuromuscular manifestations of COVID-19 in children

Marques Frank*

Department of Neuromuscular Diseases

*Corresponding Author:
Marques Frank
Department of Neuromuscular Diseases
Iwate Medical University School of Medicine

Received:16-May-2023, Manuscript No. AANN-23-99706; Editor assigned:19-May-2023, PreQC No. AANN-23-99706 (PQ); Reviewed:02-Jun-2023, QC No. AANN-23-99706; Revised:06-Jun-2023, Manuscript No. AANN-23-99706 (R); Published:13-Jun-2023, DOI:10.35841/ aann-8.3.147

Citation: Frank M. Neuromuscular manifestations of COVID-19 in children. J NeuroInform Neuroimaging. 2023;8(3):147

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The COVID-19 pandemic has affected millions of people worldwide, and while it was initially believed to primarily target the respiratory system, we have come to realize that this viral infection can have diverse and complex effects on the human body. One area of concern that has emerged is the impact of COVID-19 on the neuromuscular system, particularly in children. In this article, we will explore the neuromuscular manifestations of COVID-19 in children and the implications for their health. Although children generally experience milder symptoms of COVID-19 compared to adults, it is essential not to overlook the potential neurological complications that may arise. Reports have indicated that COVID-19 can affect the nervous system, leading to a range of neuromuscular manifestations. These manifestations can present themselves in various ways, including peripheral neuropathy, myopathy, and even stroke

One of the notable neuromuscular manifestations in children with COVID-19 is Guillain-Barré syndrome (GBS), a rare but serious condition that affects the peripheral nervous system. GBS typically occurs after an infection, and COVID-19 has been identified as a potential trigger. Children with GBS may experience muscle weakness, loss of reflexes, and, in severe cases, paralysis. Prompt recognition and management of GBS are crucial to prevent long-term complications and promote recovery. Another neuromuscular manifestation associated with COVID-19 is acute necrotizing encephalopathy (ANE), also known as acute necrotizing encephalitis. ANE is a rare but severe condition characterized by brain inflammation and damage. Although ANE is primarily seen in children, there have been reports of cases associated with COVID-19. Symptoms of ANE may include seizures, altered consciousness, and neurological deficits. Early diagnosis and intensive supportive care are vital in managing ANE in children with COVID-19 [1].

Additionally, COVID-19 has been linked to cases of myopathy, which refers to muscle disease or weakness. Studies have shown that the virus can directly invade muscle cells, leading to muscle damage and inflammation. This can result in muscle pain, weakness, and difficulty with movements. In children, myopathy associated with COVID-19 may present as muscle pain, fatigue, or even difficulty with walking or standing. Close monitoring and appropriate rehabilitation interventions are essential for managing COVID-19-related myopathy in children

Furthermore, there have been reports of stroke in children infected with COVID-19. Stroke occurs when blood supply to the brain is disrupted, leading to brain cell damage. Although strokes are relatively rare in children, COVID-19 seems to increase the risk. The exact mechanisms by which the virus predisposes children to stroke are still under investigation. It is crucial for healthcare providers to recognize the signs and symptoms of stroke in children with COVID-19 promptly to initiate appropriate medical interventions [2].

The neuromuscular manifestations of COVID-19 in children raise important concerns regarding their long-term health outcomes. While some children may experience complete recovery, others may face persistent neurological sequelae. Post-COVID-19 neurological complications in children can include cognitive impairment, motor deficits, and psychological issues. Rehabilitation programs tailored to the specific needs of these children should be implemented to optimize their recovery and quality of life [3].

As our understanding of COVID-19 continues to evolve, it is essential for healthcare professionals to remain vigilant and consider the potential neuromuscular manifestations in children. Timely recognition, early intervention, and appropriate management are key in improving outcomes for these patients. It is important for healthcare providers and parents alike to be aware of the potential neuromuscular manifestations of COVID-19 in children. Recognizing the signs and symptoms promptly and seeking appropriate medical attention can make a significant difference in the child's outcomes. Some of the common signs to watch out for include muscle weakness, loss of reflexes, seizures, altered consciousness, muscle pain, and difficulty with movements [4].

Preventive measures such as vaccination and adherence to public health guidelines remain essential in reducing the risk of COVID-19 and its associated complications in children. Vaccination not only helps in preventing severe illness but also potentially reduces the incidence of post-infection neurological complications. Following preventive measures such as hand hygiene, mask-wearing, and maintaining physical distance can further minimize the risk of COVID-19 transmission. As the COVID-19 pandemic unfolds, it is essential to prioritize the holistic well-being of children. This includes not only addressing the respiratory symptoms but also recognizing and managing potential neuromuscular manifestations. By remaining informed, taking preventive measures, and seeking timely medical attention, we can better safeguard the health and future of our children in the face of this global health crisis [5].


COVID-19 can have diverse neuromuscular manifestations in children, ranging from Guillain-Barré syndrome and acute necrotizing encephalopathy to myopathy and stroke. These complications highlight the importance of early recognition, specialized care, and rehabilitation interventions. By being vigilant and proactive, healthcare providers and parents can help minimize the impact of COVID-19 on the neuromuscular system of children and optimize their long-term health outcomes.


  1. Veerapandiyan A, Connolly AM, Finkel RS, et al. Spinal muscular atrophy care in the COVID?19 pandemic era.. Muscle & nerve. 2020;62(1):46-9.
  2. Indexed at, Google Scholar, Cross Ref

  3. Goetschius DJ, Kim Y, Kumar A, et al. A comprehensive review of neuromuscular manifestations of COVID-19 and management of pre-existing neuromuscular disorders in children. J Clin Med. 2022;11(4):934.
  4. Indexed at, Google Scholar, Cross Ref

  5. Stratton AT, Roberts Iii RO, Kupfer O, et al. Pediatric neuromuscular disorders: Care considerations during the COVID-19 pandemic. . J Pediatr Rehabil Med. 2020;13(3):405-14
  6. Indexed at, Google Scholar, Cross Ref

  7. Kim Y, Walser SA, Asghar SJ, et al. A comprehensive review of neurologic manifestations of COVID-19 and management of pre-existing neurologic disorders in children. J Child Neurol. 2021;36(4):324-30.
  8. Indexed at, Google Scholar, Cross Ref

  9. Paybast S, Gorji R, Mavandadi S. . Guillain-Barré syndrome as a neurological complication of novel COVID-19 infection: A case report and review of the literature. Neurologist. 2020;25.
  10. Indexed at, Google Scholar, Cross Ref

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