Commentary - Journal of Hypertension and Heart Care (2023) Volume 6, Issue 2
Managing atherosclerosis: lifestyle changes and medicationsAlberico James*
Department of Coronary Artery and Structural Heart Diseases, National Institute of Cardiology in Warsaw, Warsaw, Poland
- *Corresponding Author:
- Alberico James
Department of Coronary Artery and Structural Heart Diseases
National Institute of Cardiology in Warsaw, Warsaw, Poland
Received: 23-Mar-2023, Manuscript No. AAJHHC-23-97211; Editor assigned: 24-Mar-2023, PreQC No. AAJHHC-23-97211(PQ); Reviewed: 07-Apr-2023, QC No. AAJHHC-23-97211; Revised: 09-Apr-2023, Manuscript No. AAJHHC-23-97211(R); Published: 17-Apr-2023, DOI: 10.35841/AAJHHC-6.2.143
Citation: James A. Managing atherosclerosis: lifestyle changes and medications. J Hypertens Heart Care. 2023;6(2):143
Atherosclerosis is a condition in which plaque accumulates inside the walls of arteries. The plaque consists of fatty substances such as cholesterol, calcium, and other materials that are found in the blood. This buildup of plaque can lead to narrowing of the arteries, making it difficult for blood to flow through them. Atherosclerosis is a chronic and progressive disease that can affect any artery in the body but is most commonly found in the arteries that supply blood to the heart, brain, and legs.
The exact cause of atherosclerosis is not fully understood, but it is believed to be a complex process involving multiple factors such as genetics, diet, lifestyle, and environmental factors. Atherosclerosis typically begins with damage to the inner lining of an artery, which triggers an inflammatory response . This inflammation causes white blood cells to accumulate in the area, which can then absorb cholesterol and other lipids from the bloodstream, creating foam cells. Over time, the foam cells can accumulate and form a plaque that protrudes into the lumen of the artery, reducing the flow of blood.
One of the most common risk factors for atherosclerosis is high levels of cholesterol in the blood. Cholesterol is a type of fat that is essential for the body to function properly, but when there is too much of it in the blood, it can contribute to the development of atherosclerosis . High levels of LDL (low-density lipoprotein) cholesterol, also known as "bad" cholesterol, can increase the risk of atherosclerosis, while high levels of HDL (high-density lipoprotein) cholesterol, also known as "good" cholesterol, can help protect against it. Other risk factors for atherosclerosis include high blood pressure, smoking, obesity, diabetes, and a family history of the disease. Age and gender also play a role, with men over the age of 45 and women over the age of 55 being at a higher risk of developing atherosclerosis .
The symptoms of atherosclerosis depend on which arteries are affected. If the arteries that supply blood to the heart become narrow or blocked, it can cause chest pain or discomfort, known as angina. If an artery in the brain becomes blocked, it can cause a stroke. Narrowing of the arteries in the legs can cause pain when walking, known as claudication. In some cases, atherosclerosis may not cause any symptoms until it becomes severe.
Diagnosis of atherosclerosis typically involves a physical exam, medical history, and various tests. These tests may include blood tests to check cholesterol levels, imaging tests such as ultrasound, CT scan or MRI, and cardiac catheterization, which involves inserting a thin tube into an artery and injecting a contrast dye to help visualize the blood vessels.
Treatment for atherosclerosis depends on the severity and location of the disease. Lifestyle changes such as eating a healthy diet, exercising regularly, quitting smoking, and maintaining a healthy weight can help prevent or slow the progression of atherosclerosis. Medications such as statins, which are used to lower cholesterol levels, and antiplatelet drugs, which help prevent blood clots, may also be prescribed. In some cases, surgical procedures such as angioplasty or bypass surgery may be necessary to open blocked arteries .
Prevention of atherosclerosis is important for maintaining overall cardiovascular health. This includes adopting healthy lifestyle habits such as exercising regularly, eating a healthy diet that is low in saturated and trans fats, and avoiding smoking. Regular check-ups with a healthcare provider to monitor cholesterol and blood pressure levels can also help identify and manage risk factors for atherosclerosis .
In conclusion, atherosclerosis is a chronic and progressive disease that can have serious consequences if left untreated. While the exact cause of the disease is not fully understood, it is believed to be a complex process involving multiple factors. The risk of developing atherosclerosis can be reduced by adopting a healthy lifestyle and managing risk factors such as high cholesterol, high blood pressure, and smoking. Early diagnosis and treatment of atherosclerosis can help prevent complications such as heart attack, stroke, and peripheral artery disease. Regular check-ups with a healthcare provider, maintaining a healthy weight, and staying physically active are all important steps in preventing and managing atherosclerosis.
- Marques-Vidal P. Dietary measures among patients with coronary heart disease in Europe. ESC EORP Euroaspire V. Int J Cardiol.2020;302:5-14
- Hussain I, Patni N. Lipodystrophies, dyslipidaemias and atherosclerotic cardiovascular disease. Pathology.2019;51(2):202-12.
- Zhao QR, Lei YY. Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis. Clin Chem Lab Med. 2017;55(2):284-98.
- Yu XH. Pregnancy-associated plasma protein-A in atherosclerosis: Molecular marker, mechanistic insight, and therapeutic target. Atherosclerosis.2018;278:250-58.
- Shu J. Update on peripheral artery disease: Epidemiology and evidence-based facts. Atherosclerosis. 2018; 275:379-81.