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Mini Review - Archives of Digestive Disorders (2024) Volume 6, Issue 2

Immunology�s vast landscape: Protection and pathology

Kenichi Ikejima*

Department of Medicine, Juntendo University

*Corresponding Author:
Kenichi Ikejima
Department of Medicine
Juntendo University.
E-mail: Ikejima12@gmail.com

Received : 08-Jan-2024, Manuscript No. aaadd-24-178; Editor assigned : 10-Jan-2024, PreQC No. aaadd-24-178(PQ); Reviewed : 30-Jan-2024, QC No aaadd-24-178; Revised : 08-Feb-2024, Manuscript No. aaadd-24-178(R); Published : 19-Feb-2024 , DOI : 10.35841/aaadd-6.1.178

Citation: Ikejima K. Immunology's vast landscape: Protection and patholog. Arch Dig Disord . 2024;06(01):178.

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Introduction

This article presents a contemporary framework for understanding immunologic memory, distinguishing between memory cells and memory responses. It highlights how these components interact across different immune cell types to provide robust, long-term protection against pathogens, emphasizing the dynamic nature and adaptability of recall immunity [1].

Exploring the cutting-edge of innate immunity, this review discusses recent discoveries in pattern recognition receptors, inflammasomes, and immunometabolism that reveal the intricate mechanisms governing early immune responses. It also examines the potential for therapeutic targeting of these pathways to treat infectious and inflammatory diseases [2].

This article provides an updated view on the immunopathogenesis of autoimmune diseases, focusing on the complex interplay between genetic predisposition, environmental triggers, and immune dysregulation. It details how T and B cell abnormalities, cytokine imbalances, and defective regulatory mechanisms contribute to the breakdown of self-tolerance, leading to chronic inflammatory conditions [3].

Here's the thing: while chemotherapy directly targets cancer cells, it also profoundly impacts the immune system. This article meticulously outlines the various immunosuppressive effects of common chemotherapeutic agents, discussing how they can impair anti-tumor immunity and potentially influence the efficacy of concurrent immunotherapies [4].

This review delves into vaccinomics, a field that integrates genomics, immunology, and bioinformatics to accelerate vaccine discovery and development. It explores how understanding individual genetic variations influences vaccine response, offering insights into personalized vaccinology and the design of more effective and safer vaccines [5].

This article presents the 2019 update to the international classification of primary immunodeficiencies (PIDs), a critical guide for diagnosis and treatment. It categorizes PIDs based on their underlying genetic defects and immunological manifestations, reflecting the growing understanding of these rare but severe disorders [6].

What this really means is that the central nervous system isn't just a protected bystander; it's an active immune organ. This review illuminates the multifaceted roles of resident microglia and other immune cells within the Central Nervous System (CNS), discussing their involvement in both maintaining brain homeostasis and driving neuroinflammatory diseases [7].

The gastrointestinal tract houses a vast and dynamic immune system, crucial for distinguishing beneficial commensals from harmful pathogens. This article explores the intricate mechanisms by which gut-associated lymphoid tissues, epithelial cells, and the resident microbiota collaboratively shape both local and systemic immunity, impacting health and disease [8].

Let's break it down: cancer cells often rewire their metabolism to support rapid growth and evade immune detection. This review highlights the emerging field of immunometabolism in cancer, detailing how metabolic pathways within both tumor cells and immune cells influence anti-tumor responses and can be therapeutically exploited [9].

T cell costimulation is absolutely essential for effective immune responses, acting as a crucial second signal beyond antigen recognition. This article explores the molecular basis of T cell costimulatory and coinhibitory pathways, explaining how these interactions fine-tune T cell activation, differentiation, and memory formation, with profound implications for autoimmune diseases and cancer immunotherapy [10].

 

Conclusion

Immunology explores how the body protects itself, from dynamic immunologic memory distinguishing between memory cells and responses for long-term pathogen protection to the intricate mechanisms of early innate immune responses. Research highlights discoveries in pattern recognition receptors, inflammasomes, and immunometabolism, revealing pathways for treating infectious and inflammatory diseases. There's also a focus on immune dysregulation, particularly in autoimmune diseases where genetic factors, environmental triggers, and abnormalities in T and B cells lead to chronic inflammation. Another key area involves the immunosuppressive effects of cancer chemotherapies, which can hinder anti-tumor immunity and impact immunotherapy effectiveness. Beyond disease, the field delves into vaccinomics, integrating genomics and bioinformatics to advance vaccine development and personalize vaccinology. It also includes the critical classification of primary immunodeficiencies based on genetic defects and immunological features. What this really means is that immunity isn't confined to traditional organs; the central nervous system acts as an active immune organ, with microglia playing a role in brain homeostasis and neuroinflammatory diseases. Similarly, the gastrointestinal tract houses a vital immune system, collaborating with microbiota to shape local and systemic immunity. Finally, immunometabolism in cancer explores how metabolic pathways in tumor and immune cells influence anti-tumor responses. T cell costimulation, a fundamental process, fine-tunes T cell activation and memory formation, which has profound implications for treating autoimmune diseases and improving cancer immunotherapies. This broad landscape showcases the multifaceted nature of immunology.

References

    1. Wayne CC, Sabrina IK, E. JW. Immunologic memory: A conceptual framework. Cell. 2023;186(21):4485-4503.

Indexed at, Google Scholar, Crossref

    1. Luke AJO, Joshua BG, Lewis W. Innate immunity: New frontiers in its understanding and targeting. Nat Rev Immunol. 2022;22(12):737-756.

Indexed at, Google Scholar, Crossref

    1. Paola S, Stefania A, Francesco G. The immunopathogenesis of autoimmune diseases: an update. J Clin Med. 2020;9(12):3986.

Indexed at, Google Scholar, Crossref

    1. Lorenzo G, Jonathan H, Andrea B. Immunosuppressive effects of cancer chemotherapies. Nat Rev Clin Oncol. 2020;17(1):1-20.

Indexed at, Google Scholar, Crossref

    1. Gregory AP, Inna GO, Richard BK. Vaccinomics and vaccine development. Cold Spring Harb Perspect Med. 2020;10(7):a034509.

Indexed at, Google Scholar, Crossref

    1. Capucine P, H. BG, Maya S. The international classification of primary immunodeficiencies: 2019 update. J Clin Immunol. 2019;39(8):654-672.

Indexed at, Google Scholar, Crossref

    1. Marco P, Jochen P, Carolina S. The central nervous system as an immune organ: microglial cells and beyond. Science. 2021;373(6554):eabl6005.

Indexed at, Google Scholar, Crossref

    1. Jessica MP, Mu-Yan Z, Thaddeus SS. The immune system in the gastrointestinal tract. Cold Spring Harb Perspect Biol. 2021;13(1):a038198.

Indexed at, Google Scholar, Crossref

    1. Tak WM, Florian G, Manolis P. Immunometabolism in cancer. Nat Rev Immunol. 2020;20(3):159-173.

Indexed at, Google Scholar, Crossref

    1. Ronald NG, Marc KJ, Andrew HL. The molecular immunology of T cell costimulation. Immunity. 2020;52(4):585-602.

Indexed at, Google Scholar, Crossref

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