Gynecology and Reproductive Endocrinology

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Mini Review - Gynecology and Reproductive Endocrinology (2023) Volume 7, Issue 2

Fertility Issues in Girls and Women with gynecologic cancer

Kerry Wang *

Department of Gynecology, China Medical University, Shenyang, China

*Corresponding Author:
Kerry Wang
Department of Gynecology
China Medical University
Shenyang, China.

Received: 03-Mar-2023, Manuscript No. AAGGS-23-91426; Editor assigned: 07-Mar-2023, PreQC No. AAGGS-23-91426 (PQ); Reviewed:21-Mar-2023, QC No. AAGGS-22-91426; Revised:24-Mar-2023, Manuscript No. AAGGS-23-91426 (R); Published: 31-Mar-2023, DOI:10.35841/2591-7994-7.2.140

Citation: Wang K. Fertility issues in girls and women with gynaecologic cancer. Gynecol Reprod Endocrinol. 2023;7(2):140

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When cancer starts in a woman's reproductive organs, it's called gynaecologic cancer. The five main types of gynaecologic cancer are cervical, ovarian, uterine and vaginal and vulvar. Cervical cancer begins in the cervix, which is the lower, narrow end of the uterus. Ovarian cancer begins in the ovaries, which are located on each side of the uterus. Some ovarian cancers can also begin in the fallopian tubes or peritoneum. Uterine cancer begins in the uterus, the pear- shaped organ in a woman’s pelvis where the baby grows when she's pregnant. Vaginal cancer begins in the vagina, which is the concave, tube- suchlike channel between the bottom of the uterus and the outside of the body.

Reproductive organs, Cancer, Ovarian cancer, Gynaecologic cancer, Uterine cancer.


Each gynaecologic cancer is unique, with different signs and symptoms, different threat factors (effects that may increase your chance of getting a complaint) and different forestalment strategies. All women are at threat for gynaecologic cancers and threat increases with age. When gynaecologic cancers are set up beforehand treatment is most effective [1].

Fertility Issues in Girls and Women with Cancer: Numerous cancer treatments can affect a girl’s or woman’s fertility. Most probably, your doctor will talk with you about whether or not cancer treatment may increase the threat of, or beget, gravidity. Still, not all doctors bring up this content. Occasionally you, a family member, or parents of a child being treated for cancer may need to initiate this discussion [2, 3].

1. Your birth fertility 2. Your age at the time of treatment 3. The type of cancer and treatment 4. The quantum (cure) of treatment 5. The length (duration) of treatment 6. The quantum of time that has passed since cancer treatment.

A lot of exploration have made advance to study the gets and ethology of the miscellaneous group of ovarian cancers and several studies by Indian scientists demonstrate the development in this direction. studied the status of transubstantiating growth factor beta( TGF- β) signalling in mortal ovarian napkins by immunohistochemistry( IHC) and set up that pituitary home box 2( PITX2)- convinced TGF- β pathway regulated the expression of irruption- associated genes, SNAI1, CDH1 and MMP9( P<0.01) that reckoned for enhanced motility and irruption in ovarian cancers. SNAI1 and MMP9 acted as important intercessors of PITX2- convinced invasiveness of ovarian cancer cells. PITX2 overexpression redounded in the loss of epithelial labels (P<0.01) and gain of mesenchyme labels (P<0.01) that contributed significantly to ovarian oncogenes is. Delved biomarkers to help in the discovery and assessment of remedial response in epithelial ovarian cancer (EOC). Besides CA- 125, situations of tube tyrosine- lysine- leonine- 40 were significantly raised in cases with EOC (77.0; P<0.0001) and significantly dropped post-therapy. Circulating cell-free DNA (P<0.0001) and cell-free nuclear DNA (P<0.0001) situations also dropped significantly post-treatment as compared to pre-treatment situations [4].

Chemotherapy plays a major part in ovarian cancer rectifiers and remains one of the most important aspects of operation of these cases. A group of experimenters studied the primary societies of EOC cells established from ascetic fluids of undressed ovarian cancer cases and the SKOV- 3 ovarian cancer- deduced cell lines. The separate cells were treated with metformin, carboplatin and paclitaxel alone and its colourful combinations and their goods, including the capability to induce apoptosis, were examined. Metformin convinced apoptosis in the ovarian cancer cells by down regulating Bbl. - 2 and Bbl. - xilu expression and up regulating Box and cytochrome c expression and provoked a cell cycle arrest in the G0/ G1 and S- phase [5].


The apoptosis induction by metformin could be enhanced by a combinatorial use of carboplatin and paclitaxel. Another study from a tertiary cancer centre in India reported unregulated insulin- suchlike growth factor 1 receptor (IGF- 1R) expression in the early stages of cisplatin- paclitaxel and cisplatin- taxon resistance. Picropodophyllin, an IGF- 1R asset, alone and in combination with cisplatin, paclitaxel, or both at lowest possible boluses, could reverse the resistance at early stages.


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  3. De Win G, Dautricourt S, Deans R, et al. Fertility and sexuality issues in congenital lifelong urology patients: Female aspects. World J Urol. 2021;39:1021-7.
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