Journal of Clinical Endocrinology Research

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Short Communication - Journal of Clinical Endocrinology Research (2023) Volume 6, Issue 2

Exploring the role of human chorionic gonadotropin hormone: from pregnancy marker to therapeutic potential.

João Martins*

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, United States

Corresponding Author:
João Martins
Department of Medical Sciences
School of Veterinary Medicine
University of Wisconsin-Madison
United States

Received: 20-Mar-2023, Manuscript No. AAJCER-23-99963; Editor assigned: 22-Mar-2023, PreQC No. AAJCER-23-99963(PQ); Reviewed: 05-Apr-2023, QC No AAJCER-23-99963; Revised: 09-Apr-2023, Manuscript No. AAJCER-23-99963(R); Published: 14-Apr-2023, DOI:10.35841/aajcer-6.2.138

Citation: Martins J. Exploring the role of human chorionic gonadotropin hormone: from pregnancy marker to therapeutic potential. J Clin Endocrinol Res. 2023;6(2):137

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Human Chorionic Gonadotropin (HCG) is a hormone that plays a crucial role in various physiological processes within the human body. It is primarily known for its association with pregnancy, as its levels significantly increase during early stages and throughout gestation. However, hCG has diverse functions beyond pregnancy and has gained attention in the fields of medicine, fertility treatment, and performance enhancement. hCG is a glycoprotein hormone produced by the placenta, specifically the syncytiotrophoblast cells, following implantation of the fertilized egg into the uterine wall. Its primary purpose during pregnancy is to support the development and maintenance of the corpus luteum, a temporary endocrine gland that secretes progesterone. The presence of HCG in the body prevents the degeneration of the corpus luteum, ensuring an adequate supply of progesterone, which is essential for maintaining the uterine lining and supporting the growing foetus. In addition to its role in pregnancy, HCG has also been utilized in fertility treatments.

Human chorionic gonadotropin (HCG) is a hormone that plays a crucial role during pregnancy. It is primarily produced by the placenta and is responsible for supporting the growth and development of the fetus. However, in recent years, researchers have begun to uncover the therapeutic potential of hCG beyond its traditional role as a pregnancy marker. This article delves into the various aspects of hCG and its expanding significance in medicine.

Pregnancy Marker

One of the most well-known applications of human chorionic gonadotropin is its use as a marker for pregnancy detection. The hormone can be detected in a woman's urine or blood shortly after conception. Pregnancy tests often rely on the presence of human chorionic gonadotropin to determine if a woman is pregnant. Additionally, the levels of human chorionic gonadotropin can provide information about the progression of pregnancy and the health of the developing foetus.

Support for pregnancy

HCG is instrumental in supporting pregnancy by maintaining the production of progesterone, a hormone necessary for the development of the uterine lining. During the first trimester, human chorionic gonadotropin stimulates the corpus luteum in the ovary to continue producing progesterone until the placenta takes over this function. This sustained production of progesterone is essential for the implantation of the fertilized egg and the subsequent maintenance of pregnancy.

Therapeutic applications:

In recent years, researchers have been exploring the therapeutic potential of HCG beyond pregnancy-related applications. Here are some areas where HCG shows promise:

Fertility treatments: HCG is used in assisted reproductive technologies, such as in vitro fertilization (IVF), to trigger ovulation and enhance the chances of successful implantation. It can stimulate the release of mature eggs from the ovaries, facilitating fertility treatments.

Weight loss: In certain medical weight loss programs, human chorionic gonadotropin is used in combination with a lowcalorie diet to promote fat loss and preserve muscle mass. While the exact mechanisms are not fully understood, it is believed that HCG helps suppress appetite and facilitates the utilization of stored fat as an energy source.

Testicular development: In males with underdeveloped testes or low testosterone levels, HCG can be administered to stimulate testicular growth and increase the production of testosterone. This can be beneficial for individuals with delayed puberty or that seeking hormone replacement therapy.

Cancer treatment: Preliminary studies have suggested that human chorionic gonadotropin may have anti-tumour effects in certain types of cancer, including testicular, ovarian, and bladder cancer. Further research is needed to fully understand its potential in cancer treatment.

Potential Limitations and Side Effects

While HCG shows promise in various therapeutic applications, it is important to note that further research is required to establish its efficacy and safety. Like any hormone-based therapy, HCG can have potential side effects, including headache, fatigue, breast tenderness, and fluid retention. It is crucial to consult with healthcare professionals before considering hCG treatment and to closely monitor its usage.


Human chorionic gonadotropin (HCG) has long been recognized as a vital hormone during pregnancy. However, its potential extends beyond its role as a pregnancy marker. Ongoing research is shedding light on the therapeutic applications of human chorionic gonadotropin in fertility treatments, weight loss programs, testicular development, and even cancer treatment. As our understanding of human chorionic gonadotropin expands, it holds the promise of transforming medical interventions and improving patient outcomes in various fields. Nonetheless, further research and clinical trials are necessary to fully harness the therapeutic potential of HCG and ensure its safe and effective use in different contexts.


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