Biomedical Research

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- Biomedical Research (2014) Volume 25, Issue 1

Diabetes risk 10 years forecast in the capital of Saudi Arabia: Canadian Diabetes Risk Assessment Questionnaire (CANRISK) perspective.

Ahmad Alghadir1, Hamzeh Awada1*, Einas Al-Eis2, Alia Alghwiri2

1Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

2Department of Physical Therapy, Faculty of Rehabilitation Sciences, The University of Jordan, Amman, Jordan

*Corresponding Author:
Hamzeh Awad
Rehabilitation Research Chair
Saudi Arabia
King Saud University
P.O. Box 2925, Riyadh 11461

Accepted November 14 2013

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The prevalence of diabetes type 2 (DMT2) in Saudi Arabia has been increased dramatically. The early detection of diabetes is crucial in delaying the process of the disease. The Canadian Risk (CANRISK) is a self-administered questionnaire used to identify people at high risk for developing diabetes. The main objective of this study was to utilize the CANRISK to evaluate the diabetes risk among participants in the capital of Saudi Arabia (Riyadh). In this cross-sectional study design, the CANRISK was administered to a convenience sample of people (603) in Riyadh by healthcare professionals. Six hundred and three participants were recruited from public areas of Riyadh, Kingdom of Saudi Arabia, to participate in this study. The mean total CANRISK score for this study was 33.24(SD±11.36) with a range from 9 to 68. Women had significantly higher CANRISK total scores than did men in both moderate and high risk categories. High CANRISK score is emphasizing that more than half of the study participants have high risk for developing DMT2. Thus, urge the need for efforts to minimize sedentary lifestyle in Saudi general population.


Diabetes Mellitus (DM), Canadian Risk (CANRISK), Body Mass Index (BMI), Prediabetes, Screening


The prevalence of diabetes has been increasing enormously at an alarming rate worldwide. Worldwide approximately 366 million people suffer from diabetes mellitus in 2011, some 80% of whom live in low- and ]. Prevalence of diabetes in 1middle-income countries [ Saudi Arabia is among the highest globally, affecting 23.7% of the Saudi population [2].

Despite high rates of undiagnosed diabetes and prediabetes in Middle East, the assessment tools currently used to estimate an individual’s risk of diabetes are lacking. It is clinically important to be able to identify individuals at risk of diabetes. First, undiagnosed diabetes often remains undetected for 4 to 7 years before clinical diagnosis, and many newly diagnosed patients already exhibit signs of micro- and macro-vascular complications [3,4]. Second, individuals with prediabetes (Impaired Fasting Glucose [IFG] and/or impaired glucose tolerance [IGT]) have a high likelihood of developing DMT2 (10 to 20) times than of normoglycemic persons [5,6]

Worldwide, large randomized experimental studies such as the Finnish Diabetes Prevention Study [7] and the US have demonstrated that [8] Diabetes Prevention Program lifestyle intervention can effectively reduce the incidence of diabetes among those with prediabetes. Risk-scoring questionnaires may be useful to enhance individual risk assessment. Most risk-scoring models for DMT2 require specific blood test results [9-16], which presumes that a clinical encounter or diagnostic testing has already taken place. This limits widespread use of these models from a public health perspective. A diabetes risk assessment approach that relies on information a participant can selfcomplete without detailed knowledge of specific laboratory test values has been developed in Finland [17].

The Finnish Diabetes Risk Score [17] FINDRISC was adapted to include ethnicity and other key variables, such as gender and level of education to create the Canadian Diabetes Risk Assessment Questionnaire (CANRISK) [18], which has been widely used to identify those who are at risk of developing diabetes.

The countries of the Gulf Cooperation Council (GCC), share a similar culture and ethnicity, while their sociodemographic distributions and socioeconomic development are also similar [19]. Although the countries of the GCC have experienced noticeable advances in delivering healthcare, the burden of non-communicable diseases is increasing rapidly [20] the prevalence of obesity in these countries, which is associated with multichronic diseases (i.e diabetes) exceeds that in the developed countries because of their rapid economic growth and associated changes in lifestyle [21-23]. Furthermore, the International Diabetes Federation reports that five of the countries of the GCC ranked globally among the top ten countries in the world for diabetes prevalence [24].

The main objective of this study was to describe the diabetes risk among participants in the capital of Saudi Arabia (Riyadh) using CANRISK.

Material and Methods

Recruitment and Participants: Participants for this study were recruited from local gathering social centers areas, i.e. Estarahes (party lounges), markets, malls and parks in Riyadh, Saudi Arabia. All participants were healthy community-dwelling adults who gave their informed consent to participate and were residents of Riyadh with no history of diabetes. The study targeted males and females adults between the ages of 40 and 74 years of age in the period June-2012 to October-2012. Exclusion criteria for this study was previous diagnosis of Type I or II diabetes.

Study Design: In this cross-sectional study design, the CANRISK (CANadian RISK) evaluation tool was utilized to determine each participant’s risk for diabetes or pre-diabetes. The CANRISK questionnaire is a tool designed in 2009 to evaluate a person’s risk of developing type II diabetes or pre-diabetes. The CANRISK is an adaptation to the Canadian population from the FINDRISC (the Finnish Diabetes Risk Score) by including language to better evaluate the Canadian population, such as smoker vs. non-smoker, ethnic origin of the participants’ parents, any history of gestational diabetes in women and family history of diabetes. The CANRISK also includes questions regarding level of education and a selfevaluation of current health status in order to further evaluate the demographics of those evaluated (18). The CANRISK was administered by physical therapist research assistant or another health professional. As the original CANRISK tool is written in English, the data collectors were fluent in English, and participants were with good knowledge of English. Data collectors were trained and asked to revise the questionnaire with participants to insure the accurate knowledge and facilitate the accuracy of the information.

Outcomes: Variables of the questionnaire will be useful in drawing a picture of the risk of diabetes in the Saudi’s population. This study examined the following variables: body mass index (BMI), waist circumference, physical activity, daily consumption of fruits & vegetables, use of anti-hypertensive medication, history of high blood glucose, and family history of diabetes. The risk of developing DMT2 within 10 years is categorized as low, slightly elevated, moderate, high, and very high as per instructions the original validated tool.

Ethical consideration: Ethical approval was obtained from the Ethics and Research Committee at King Saud University. The recruitment of potential participants was accomplished after explaining the objectives of the study by trained field research assistants. Participation was voluntary and consent was acquired from each participant. Confidentiality of all participants was maintained as no names were requested in the questionnaires.

Data Analysis: Statistical analysis was performed using IBM SPSS version 20. Descriptive statistics were used for frequencies and percentage of the answers as well as for the mean and standard deviation of total score. The t-test for 2 independent samples was performed between male and female (gender) to explore significant differences between them on CANRISK total score categories.


Six hundred and three (603) participants were recruited from public areas of Riyadh, Kingdom of Saudi Arabia, to participate in this study. The mean total CANRISK score for this study was 33.24 (SD=11.36) with a range from 9 to 68.With regards to the total scores for each participant of this study, more than half of them (53%)ranked in the category of high risk for developing diabetes (Table 1). By using the independent t-test, we found that women had significantly higher CANRISK total scores than did men in both moderate and high risk categories (Table 2), indicating that women had higher risk of developing DMT2 that did men. Level of P-value demonstrated statically relation (males and females) from one side and (moderate and high) total risk from the other side.


Table 1: Results of CANRISK specific items and total score between males and females.


Table 2: Mean and Standard Deviation (SD) of CANRISK total score between males and females.


This study’s sample consisted of 73% males and 27% females. Table 1 presents a breakdown of the CANRISK results of specific items compared between males and females. While examining BMI, the mean BMI across all participants was 29.23 (SD=5.29) with a range of 15.37 to 57.33. Waist circumference was also examined using the tape measurement. More than half of participants; 53% of males and 58% of females, measured at the highest category of waist circumference indicating higher risk of developing diabetes.

According to the CANRISK questionnaire, women were questioned as to whether they had given birth to a large baby weighing 9 pounds. For those women answering in the affirmative, only 7% had developed gestational diabetes. With regards to ethnic groups, CANRISK divided ethnicity into 6 categories: White; Aboriginal; Black; East Asian; South Asian; and other non-white including Arab. However, all participants’ parents in this study were Arabic origins.

Educational levels for all participants were divided into “some high school or less” with 218 (36%) participants; “high school diploma” with 119 (20%) participants; “some college or university” and “university or college degree with 266 (44%) participants.

The mean, SD and 95% Confidence Interval for each item categories of CANRISK is presented in (Table 3). By looking at age, it is obvious that older participants scored higher in CANRISK total score for all age categories. Regarding BMI and waist circumference, participants with greater BMI and waist circumference had higher CANRISK total score. Similarly, participants who mentioned doing regular physical activity and consuming vegetable or fruit daily had smaller CANRISK total score. However, the difference in mean CANRISK score was not that high between participants who mentioned consuming vegetables or fruits daily and participants who did not. Additionally, participants who had history of high blood pressure, high blood sugar, and gestational diabetes scored higher in CANRISK total score. When asked about relatives with DM, participants who had more relatives with DM scored higher in CANRISK total score. Similarly, participants with university or college degree had smaller CANRISK total score than participants with high school diploma and participants with some high school or less education.


Table 3: Mean and standard deviation (SD) with 95% confidence interval of the mean of CANRISK total score for each item categories.


The main aim of this study was to describe the diabetes risk among participants in the capital of Saudi Arabia (Riyadh) using CANRISK. The outcomes of the CANRISK questionnaire were useful in drawing a picture of the risk of diabetes in the residents of Riyadh. Knowing the size of this problem in Saudi Arabia would be an important addition to the current literature around the world. Additionally, the current study contributes in drawing the attention of local policy makers for preventive strategies to decrease the incidence of getting diabetes. Moreover, the current results may encourage other Arab countries to evaluate such a risk in their populations.

This study searches for possible justification of high risk factors and to what extent it supports our study outcomes with regard to modifiable risk factors (such as BMI and a sedentary lifestyle). As it is accepted fact that the number of diabetic patients in Saudi Arabia is high and it is also increasing very rapidly due to lifestyle changes. In the CANRISK, most of the variables used to predict risk of DMT2 within 10 years are related to lifestyle. Therefore, it would be appropriate to apply CANRISK in spite of race/ethnicity or cultural differences.

Risk factors for type 2 diabetes


Our study represented that just below 50% of males and females participants are overweight with BMI score range [25-29] due to CANRISK. Such result supports the notion that risk of diabetes development is higher among participants with higher BMI. Indeed, there is strong evidence in literature with longitudinal studies showing that increased BMI is a strong risk factor for DMT2 [25,27]. A strong positive association between obesity and DMT2 is found both in men [26-28], and women [26,27,29].


CANRISK demonstrated that about third of males and females suffered from hypertension. previous studies showed that hypertension progression is an independent predictor of DMT2 [30-32]. Several possible factors are likely causes of the association between DMT2 and hypertension. Endothelial dysfunction could be one of the common pathophysiological pathways explaining the strong association between blood pressure and incident of DMT2. Clinical perspective indicate that markers of endothelial dysfunction are associated with new-onset of diabetes [33,34]. Insulin resistance could be another possible link between blood pressure levels and the incidence of DMT2 [35].

Central obesity and waist circumference

This study outcomes demonstrated that large waist circumference was prevalent among participants with more than 50% over 102 cm. Since the central obesity defined as the waist circumference >102 cm for males and >88 cm for females; our data revealed that approximately half of males and females suffered from central obesity. Evidence is now emerging that obesity-driven DMT2 might become the most common form of diabetes in adolescents within the next ten years [36].

Physical activity and dietary pattern

WHO and diabetes association’s world-wide developed Global Strategy on Diet, Physical Activity and Health. WHO stated that unhealthy diets and physical inactivity are among the leading causes of the major noncommunicable diseases, including cardiovascular disease, DMT2 and certain types of cancer, and contribute substantially to the global burden of disease, death and disability [37]. Regardless of this alarm from WHO since 2004, the study participants were not physically active, just above two third of men and women participants reported that they are not physically active. Also, nearly half of women and men participants reported not eating vegetables or fruits every day. However, the CANRISK does not take into account the type or frequency of physical activity as well as types of vegetables and fruits. Longitudinal studies revealed that physical inactivity is a strong risk factor for DMT2 [27,38-41]. Prolonged television watching as a surrogate marker of sedentary lifestyle, was reported to be positively associated with diabetes risk in both men and women [42-44].

In literature, moderate and vigorous physical activity is associated with a lower risk of DMT2 [38,45]. Evidence from clinical trials which included physical activity as an integral part of lifestyle interventions suggested that onset of DMT2 can be prevented or delayed as a result of successful lifestyle interventions that included physical activity [46]. Physical activity plays an important role in delaying or preventing the development of DMT2 in those at risk both directly by improving insulin sensitivity and reducing insulin resistance, and indirectly by beneficial changes in body mass and body composition [47-49].

An important life style factor associated with the development of DMT2 is dietary habits. Positive association has been reported between the risk of DMT2and different patterns of food intake [50]. Higher dietary glycemic index has been consistently associated with elevated risk of DMT2 in prospective cohort studies [51-53]. A prospective study found that regular consumption of white rice is associated with an increased risk of type 2 diabetes whereas replacement of white rice by brown rice or other whole grains was associated with a lower risk [51]. A review which included 19 studies concluded that a higher intake of polyunsaturated fat and long- chain fatty acid is beneficial, whereas higher intake of saturated fat and trans fat adversely affects glucose metabolism and insulin resistance [54]. Another prospective study found higher consumption of butter, potatoes and whole milk to be associated with increased risk of DMT2. Higher consumption of fruits and vegetable was associated with reduced risk of DMT2 [55]. However, CANRISK is not looking in details about the type or frequency of food. Therefore, modification could be recommended when one admit CANRISK in future work.


The current study reported that just under quarter of the participants have direct one or two relatives who have been diagnosed with diabetes, males percentage were higher than females with consideration to this point, this might be to large number of males compare to females in this study. Such outcomes of having 1,2, or more direct relatives would support the notion of increasing their risk in developing diabetes as several studies have found that genetic components plays an important role in pathogenesis of DMT2 [56-58]. Several prospective studies and cross sectional studies have reported that positive family history among first degree relatives gives an increased risk of DMT2 and the risk is greater when both parents are affected [56-60]. Also, diabetes prevalence varies substantially among different ethnic groups [61]. However, there was no diversity in ethnicity among Riyadh participants since our participants were all Arab and local.

Indeed, it is generally agreed that DMT2 is a poly etiological disorder. The genetic background, environmental factors, and the interaction between these all influence the development of the disease. This implies that of our sample had a genetic predisposition to develop DMT2, in addition to the high consanguinity rate among Saudi citizen [62].

Educational level

There is a considerable burden of DMT2 attribute to socioeconomic and lower educational levels in many countries [63] .Socioeconomic inequalities in health have been acknowledged in the scientific literature for more than 30 years [64] and a socioeconomic attribute for many diseases such as coronary heart disease and DMT2 [65]. The study finding demonstrated that lower level of education had a higher mean and confidence interval comparing to higher education. This may shed the light on the importance of this item in DMT2 risk assessment and ultimately in prevention.


DMT2 is a significant public health problem worldwide as well as in KSA. The current study provides insight into the progression and onset of DMT2 among Saudi nondiabetic population within next 10 years. Third of the study participants have high risk for developing DMT2 (one in three). Furthermore, females have higher risk to develop diabetes than males from CANRISK perspective. Therefore, there is a great need to address an effective obesity prevention program, taking into account the cultural context, to stop the wave of obesity and ultimately the wave of diabetes in KSA. Although the current results were based on a small sample size in the capital of Saudi Arabia, Riyadh data and experience can be generalized and used across regions in the kingdom and facilitate any implementation for any effective national plan addressing the cultural context in each region.


The language of the CANRISK questionnaire is in English which prohibited us from giving the self-report questionnaire to the participants with no knowledge in English language. Also, one may suggest that a bigger sample with longer period in different areas across the kingdom matching with gender will draw a better picture about the estimated 10 years forecast in every single region (North, East, West, East) individually and across the country. Although the survey were randomly selected, a respondent bias may have possibly existed that could have skewed the results. Modification in physical activities and diet to ask more details about the frequencies will add valuable meaning for DMT2 risk prediction.


The authors extend their appreciation to the College of Applied Medical Sciences Research Center and the Deanship of Scientific Research at King Saud University for funding this research.


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