The Cognitive Neuroscience Journal

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Mini Review - The Cognitive Neuroscience Journal (2022) Volume 5, Issue 5

COVID-19's neurological disorder and its mechanisms

Eleonora Mura*

Department of Neurology, University of Singapore, Australia.

*Corresponding Author:
Eleonora Mura
Department of Neurology
University of Singapore

Received:27-Sep-2022,Manuscript No. AACNJ-22-79519; Editor assigned: 30-Sep-2022, PreQC No. AACNJ-22-79519(PQ); Reviewed: 14-Oct-2022, QC No. AACNJ-22-79519; Revised: 17-Oct-2022, Manuscript No. AACNJ-22-79519(R); Published:21-Oct-2022, DOI:10.35841/aacnj-5.5.123

Citation: Mura E. COVID-19's neurological disorder and its mechanisms. J Cogn Neurosci. 2022;5(5):123

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Across the globe, the COVID-19 pandemic has forced governments to implement drastic containment and social distancing measures. Italy the first European country to be affected by the emergency, reported its first case of SARS-CoV-2 infection on. To limit the spread of the infection, the Italian government responded to the outbreak with a series of progressive control measures. Schools were closed in six northern districts on and nationwide SARS-CoV-2 has a distinct neurogenicity. After binding to her ACE2 receptors in the nasal epithelium, it enters the olfactory nerves and bulbs and enters the respiratory center of the brainstem. Irreversible respiratory failure may explain the poor prognosis of COVID-19 ventilator dependent patients.SARS-CoV-2 binds to her ACE2 receptors on endothelial cells and causes endothelial inflammation. Stroke occurs as a result of a prothrombotic condition due to endotheliitis. Multiple organ failure results from viral entry into ACE2 receptors in the lungs, kidneys, gut, and brain [1]

Functional neuropathy is common in neurological practice. A new approach to proactively diagnose this disorder focuses on recognizable patterns of symptoms and signs that are actually experienced. Psychological stressors, which are common risk factors for functional neuropathy, are often absent. Four entities, functional seizures, functional movement disorders, persistent postural vertigo, and functional cognitive disorders, share similarities in etiology and pathophysiology, and are disorders at the interface between neurology and psychiatry. is a variant of All four entities have unique characteristics and can be diagnosed with the support of clinical neurophysiological studies and other biomarkers. The pathophysiology of functional neuropathy includes over activity of the limbic system, development of internal symptom models as part of predictive coding frameworks, and dysfunction of brain networks that give movement a sense of spontaneity. Evidence supports individualized multidisciplinary treatment, including physical and psychotherapeutic approaches [2].

The cost-benefit effects of these measures are now hotly debated. The scope of this stakeholder debate is now expanding as more aspects are analyzed. As paediatric neuropsychiatrists, we have a particular interest in identifying the pros and cons of lockdowns for children with neurological disorders. Children with disabilities are a particularly vulnerable population whose complex needs must be taken into account when developing health policies affecting them, especially in acute emergencies like the current one [3].

We also recorded all emergency department visits and hospital admissions during the study period and examined whether participating children had a swab test to confirm laboratory SARS-CoV-22 infection. A comprehensive review of reported neuropathies during the current COVID-19 pandemic has shown that infection with SARS-CoV-2 affects the Central Nervous System (CNS), Peripheral Nervous System (PNS), and muscles [4].

Headache and decreased responsiveness. Anosmia, hyposmia, hypogastria, and dyspepsia are common early symptoms of coronavirus infection. Respiratory failure, a deadly symptom of COVID-19, which is responsible for deaths worldwide, is likely of neurogenic origin, with the virus invading cranial nerves I and spreading to the rhinoceros and brainstem. can spread to the respiratory center of the Cerebrovascular disease, particularly ischemic large-vessel stroke, and rarely cerebral venous thrombosis, intracerebral haemorrhage and subarachnoid haemorrhage, are usually thrombotic events caused by viral binding to ACE2 receptors on the endothelium and extensive arterial and venous endotheliitis. Acute hemorrhagic necrotizing encephalopathy is associated with a cytokine storm. Frontal hypo perfusion syndrome was confirmed. There are separate reports of seizures, encephalopathy, meningitis, encephalitis, and myelitis. Neuropathies affecting the PNS and muscles are less common in COVID-19 and include Guillain-Barre syndrome. Miller-Fischer syndrome; polyneuritis cranial is a rare case of viral myopathy with rhabdomyolysis. The main conclusion of this review is the urgent need to define the neurology of COVID-19, its frequency, symptoms, neuropathology and etiology. On behalf of the World Federation of Neurology, we call on national and regional neurological societies to create local databases for reporting cases with neurological symptoms observed during the ongoing pandemic. International neuroepidemiological collaborations help define the natural history of this global problem. SARS-CoV meningoencephalitis was detected in CSF using RT-PCR and viral RNA in two patients with severe respiratory symptoms and generalized convulsions who were hospitalized during the severe outbreak of SARS [5].



  1. Azhideh A.Neurological manifestation of COVID-19:a literature review.J Clin Neurosci. 2020;7(4):164-70.
  2. Indexed at, Google Scholar, Cross ref

  3. Astore C, Skolnick J.Prediction of severe adverse events, modes of action and drug treatments for COVID-19’s complications. Sci Rep. 2021;11(1):1-4.
  4. Indexed at, Google Scholar, Cross ref

  5. Pallanti S.Neurocovid-19: A clinical neuroscience-based approach to reduce SARS-CoV-2 related mental health sequelae. Psychiatry Res. 2020;130:215-7.
  6. Indexed at, Google Scholar, Cross ref

  7. Hassan M.SARS-CoV-2 infection with pneumonia and encephalitisBrain Haemorrhages.2021 ;2(3):134-6.
  8. Indexed at, Google Scholar, Cross Ref

  9. Greer CE.Isolated cranial nerve 6 palsy in 6 patients with COVID-19 infection.JNOR.2020;40(4):520-2.
  10. Indexed at, Google Scholar, Cross Ref

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