Journal of Diabetology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Short Communication - Journal of Diabetology (2022) Volume 6, Issue 1

Complications, clinical aspects and management of diabetic peripheral neuropathy.

Joannah Nate*

Division of Endocrinology, Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, USA

*Corresponding Author:
Joannah Nate
Division of Endocrinology, Kaiser Permanente of Georgia and the Division of Endocrinology
Emory University School of Medicine
Atlanta, USA
E-mail: [email protected]

Received: 30-Dec-2021, Manuscript No. AADY-22-102; Editor assigned: 03-Jan-2022, PreQC No. AADY-22-102(PQ); Reviewed: 17-Jan-2022, QC No AADY-22-102; Revised: 20-Jan-2022, Manuscript No. AADY-22-102(R); Published: 27-Jan-2022, DOI:10.35841/aady-6.1.102

Citation: Nate J. Complications, clinical aspects and management of diabetic peripheral neuropathy. J Diabetol. 2022;6(1):102

Visit for more related articles at Journal of Diabetology

Introduction

DPN (diabetic peripheral neuropathy) is a common long-term diabetes complication. It has significant clinical consequences, including foot ulceration, leg amputation, and neuropathic pain (painful-DPN). DPN is often identified late, when irreversible nerve damage has occurred, and the first indication may be a diabetic foot ulcer. A variety of novel diagnostic approaches can be employed to supplement clinical examination and aid in the early detection of DPN. DPN and painful-DPN therapy are also banned. Only stringent glucose management has been demonstrated to lower the risk of DPN in those with type 1 diabetes [1].

Because of two key clinical consequences: diabetic foot ulceration and neuropathic pain, DPN is connected to an elevated risk of death and morbidity. Diabetic foot ulcers are produced by a complex mix of risk factors and patient behaviours, with sensory loss due to DPN being the most common cause. Diabetes' lower-limb complications are costly and burdensome for patients, with potentially lethal outcomes such as amputation and death.

Analytic features of diabetic peripheral neuropathy

Acute sensory neuropathy: Many of the symptoms of acute sensory and chronic sensorimotor neuropathy are the same, despite major differences in onset, accompanying indicators, and prognosis. At night, all unpleasant neuropathic symptoms are more likely to worsen. Patients with suspected acute sensory neuropathy may have a normal clinical examination, but sensory testing may reveal allodynia (pain induced by a nonnoxious stimulation), a normal motor exam, and occasionally reduced ankle reflexes [2].

Maintaining consistent blood glucose levels is the most important part of controlling this condition. Stability may be a key characteristic since blood glucose flow (as assessed, for example, by the M value, a measure of glycemic excursions from the mean) is connected to discomfort. The majority of people, however, will require medication as a result of neuropathic pain. The quantity and number of drugs required in acute sensory neuropathy may be higher. The development of this acute neuropathy is acute or subacute, although the severe symptoms normally fade away within a year, unlike the considerably more common chronic DPN [3].

Chronic sensorimotor neuropathy: Diabetic neuropathy is one of the most unpleasant and potentially dangerous side effects of the disease. Many people are asymptomatic, and their neurological disability is only discovered by chance during a routine neurological examination. The sensory manifestations of chronic DPN are most obvious in the lower limbs because it is a length-dependent illness, but the fingers and hands may also be affected in more severe cases. Each patient's symptoms are usually unique, but they are persistent throughout their neuropathy history. It's often difficult for people to express their symptoms because they're different from other types of pain they've had before.

Unsteadiness is increasingly recognised as a sign of chronic DPN, which is produced by impaired propriaception and possibly abnormal muscular sensory function. Many patients will have both positive and negative (painful and nonpainful) sensations at the same time. Individuals with persistent DPN frequently experience symmetrical sensory loss across all modalities in a stocking distribution. This can extend all the way up to the mid-calf area, and it can even affect the upper limbs in severe cases. Ankle reflexes are usually reduced or absent, and knee reflexes may be affected as well [4].

Management of diabetic peripheral neuropathy

Initial therapy and counselling: Once a diagnosis has been made, providing patients with a full explanation of their disease, assuaging their fears and misconceptions, and assuring them that their pain may lessen with time can be extremely motivating. Simple physical therapy, such as raising bedclothes away from hyperaesthetic skin with a bed cradle, can help. It's also possible to get suggestions on which shoes to wear. In patients with relatively moderate pain, simple analgesics or anti-inflammatory drugs may be sufficient to ease discomfort.

Metabolic control: The most successful technique to achieve long-term normoglycemia is by pancreas or islet cell transplantation. This is not possible in most cases since it is only available to patients with end-stage diabetic nephropathy who have combined pancreas and kidney transplants, or in rare cases of young people with type 1 diabetes.

Although there have been no randomised, controlled trials of intensive insulin treatment for diabetic neuropathy, evidence from a number of observational studies suggests that maintaining stable glycemic control is the most essential component. Uncomfortable sensations were associated to erratic blood glucose management, according to a new study using continuous glucose monitoring. Switching to insulin, on the other hand, does not appear to provide pain relief for people whose diabetes has been adequately treated with oral hypoglycemic medicines [5].

Pharmacological management: A wide range of medicinal drugs have been indicated for the treatment of painful symptoms. Despite the lack of evidence to support the use of nonsteroidal and anti-inflammatory drugs in the treatment of DPN, some doctors may prescribe them for patients with mild symptoms. Such medications must be used with caution in neuropathic diabetic patients since many will have renal impairment, which is normally a contraindication to the use of nonsteroidal agents.

References

  1. Boulton AJM, Vinik AI, Arezzo JC, et al. Diabetic neuropathies: A statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956-62.
  2. Indexed at, Google scholar, Cross Ref

  3. Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115(3):387-97.
  4. Indexed at, Google scholar, Cross Ref

  5. Tesfaye S. Advances in the management of diabetic peripheral neuropathy. Curr Opin Support Palliat Care. 2009;3(2):136-43.
  6. Indexed at, Google scholar, Cross Ref

  7. O’Connor AB. Neuropathic pain: Quality-of-life impact, costs and cost effectiveness of therapy. PharmacoEconomics. 2009;27(2):95-112.
  8. Indexed at, Google scholar, Cross Ref

  9. Deshpande MA, Holden RR, Gilron I. The impact of therapy on quality of life and mood in neuropathic pain: what is the effect of pain reduction. Anesth Analg. 2006;102(5):1473-79.
  10. Indexed at, Google scholar, Cross Ref

Get the App