Journal of Dermatology Research and Skin Care

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Rapid Communication - Journal of Dermatology Research and Skin Care (2023) Volume 7, Issue 2

Brief note on immune modulators for skin disorders.

Stephen Leung*

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

*Corresponding Author:
Stephen Leung
Department of Dermatology
Second Xiangya Hospital, Central South University
Changsha, China

Received:31-Mar-2023,Manuscript No. AADRSC-23-97255; Editor assigned: 03-Apr-2023, PreQC No. AADRSC-23-97255(PQ); Reviewed:17-Apr-2023, QC No. AADRSC-23-97255; Revised:22-Apr-2023, Manuscript No. AADRSC-23-97255(R); Published:29-Apr-2023, DOI: 10.35841/aadrsc- 7.2.145

Citation: Leung S. Brief note on immune modulators for skin disorders. Dermatol Res Skin Care. 2023; 7(2):145

Visit for more related articles at Journal of Dermatology Research and Skin Care


Immune modulators as a treatment option for skin disorders. Immune modulators work to regulate the immune system's response, reducing inflammation and preventing the formation of skin lesions. Corticosteroids, calcineurin inhibitors, and biologic medications are commonly used for skin disorders like eczema and psoriasis. While immune modulators can improve symptoms and quality of life, they also come with some risks, and it is important to work closely with a healthcare provider to determine the appropriate medication and dosage.


Immune modulators, Skin disorders, Eczema, Psoriasis, Corticosteroids, cal$cineurin inhibitors, T-cells.


Skin disorders can be a source of discomfort and embarrassment for those who suffer from them. From eczema to psoriasis, many skin conditions can impact a person's quality of life. Immune modulators are a class of medications that can be used to manage a variety of skin disorders by helping to regulate the immune system's response. In this article, we will explore the role of immune modulators in treating skin disorders.[1].

Immune modulators

Immune modulators are medications that work to regulate the immune system. They can either suppress or stimulate the immune response, depending on the individual's needs. Immune modulators can be used to manage a range of conditions, including autoimmune disorders, cancer, and infectious diseases.

Immune modulators for skin disorders

Skin disorders often involve an overactive immune system response. In many cases, immune cells mistakenly attack healthy skin cells, leading to inflammation and the development of skin lesions. Immune modulators can be used to help manage these conditions by regulating the immune response.[2].

One class of immune modulators that is commonly used for skin disorders is corticosteroids. These medications work by suppressing the immune response and reducing inflammation. They are often prescribed for conditions like eczema, psoriasis, and dermatitis. Corticosteroids are available in different strengths and formulations, including creams, ointments, and gels. They can be applied topically to the affected area or administered orally or by injection in more severe cases.[3].

Another class of immune modulators used for skin disorders are calcineurin inhibitors. These medications work by inhibiting the activity of immune cells called T-cells. T-cells play a critical role in the immune system's response to skin disorders, and inhibiting their activity can help to reduce inflammation and prevent skin lesions from forming. Calcineurin inhibitors are often used to manage conditions like eczema and psoriasis, and they are available in topical formulations. Immunomodulators that target specific proteins involved in the immune response have also been developed for skin disorders. For example, biologic medications like adalimumab and etanercept target tumor necrosis factor-alpha (TNF-alpha), a protein involved in inflammation. These medications are often used to manage psoriasis and other autoimmune skin disorders.[4].

Benefits and risks of immune modulators

Immune modulators can provide significant relief for individuals with skin disorders, improving symptoms like itching, redness, and inflammation. However, these medications do come with some risks. Corticosteroids, for example, can cause skin thinning, discoloration, and other side effects when used long-term. Calcineurin inhibitors can increase the risk of skin infections and certain types of cancer. It is important to work closely with a healthcare provider when using immune modulators for skin disorders. They can help to determine the most appropriate medication and dosage for the individual's needs, and monitor for any potential side effects.[5].


Immune modulators are a valuable tool in managing a range of skin disorders, from eczema to psoriasis. These medications work by regulating the immune system's response, reducing inflammation and preventing skin lesions from forming. While they do come with some risks, the benefits of immune modulators can significantly improve the quality of life for those living with skin disorders. If you are struggling with a skin condition, talk to your healthcare provider to determine if immune modulators may be an appropriate treatment option for you.


  1. Agak GW, Qin M, Nobe J, et al.Propionibacterium acnes induces an IL-17 response in acne vulgaris that is regulated by vitamin A and vitamin D.J Invest Dermatol. 2014;134(2):366-73.
  2. Indexed at, Google Scholar, Cross Ref

  3. Balato A, Schiattarella M, Lembo S, et al.Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid.Arch Dermatol Res. 2013;305:255-62.
  4. Indexed at, Google Scholar, Cross Ref

  5. Bleasel NR, Stapleton KM, Lee MS, et al.Vitamin A deficiency phrynoderma: due to malabsorption and inadequate diet.J Am Acad Dermatol. 1999;41(2):322-4.
  6. Indexed at, Google Scholar, Cross Ref

  7. Buccheri L, Katchen BR, Karter AJ, et al.Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection.Arch Dermatol. 1997;133(6):711-5.
  8. Indexed at, Google Scholar

  9. Ferran M, Galván AB, Rincón C, et al.Streptococcus induces circulating CLA+ memory T-cell-dependent epidermal cell activation in psoriasis.J Invest Dermatol. 2013;133(4):999-1007.
  10. Indexed at, Google Scholar, Cross Ref

Get the App