Research and Reports in Pulmonology

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Rapid Communication - Research and Reports in Pulmonology (2023) Volume 4, Issue 3

Atypical pneumonia:Unconventional pathogens and clinical manifestations.

Gail J DiNubile*

Merck Research Laboratories, West Point, PA, USA

*Corresponding Author:
Gail J DiNubile
Merck Research Laboratories
West Point, PA, USA

Received: 30-May-2023, Manuscript No. AARRP-23-103832; Editor assigned: 01-June-2023, PreQC No. AARRP-23-103832(PQ); Reviewed: 15-June-2023, QC No. AARRP-23-103832; Revised: 20-June-2023, Manuscript No. AARRP-23-103832(R); Published: 27-June-2023, DOI: 10.35841/aarrp-4.3.143

Citation: DiNubile G.J. Atypical pneumonia:Unconventional pathogens and clinical manifestations. Res Rep Pulmonol. 2023;4(3):143

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Atypical pneumonia refers to a specific subset of pneumonia cases caused by unconventional pathogens, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and respiratory viruses. These pathogens differ from typical bacterial causes of pneumonia and often present with milder symptoms, leading to the term "walking pneumonia." However, despite the less severe presentation, atypical pneumonia can still result in significant morbidity if not promptly recognized and treated [1].

Mycoplasma pneumoniae: Mycoplasma pneumoniae is a common cause of atypical pneumonia, especially in young adults and school-aged children. It often presents with a gradual onset of symptoms, including persistent cough, sore throat, and malaise. Chlamydophila pneumoniae: Chlamydophila pneumoniae is another common pathogen associated with atypical pneumonia. It shares similarities in clinical presentation with Mycoplasma pneumoniae, with symptoms including cough, headache, and low-grade fever [2].

Legionella pneumophila: Legionella pneumophila is responsible for severe cases of atypical pneumonia, known as Legionnaires' disease. It is often associated with water sources and can cause severe respiratory symptoms, high fever, and multiorgan involvement. Respiratory Viruses: Certain respiratory viruses, such as influenza, respiratory syncytial virus (RSV), and adenovirus, can also cause atypical pneumonia. These viral infections may present with cough, fever, and respiratory distress [3].

Atypical pneumonia often presents with a more indolent course compared to typical bacterial pneumonia. Common symptoms include persistent cough, sore throat, headache, and fatigue. However, the absence of classic symptoms, such as high fever and productive cough, can make the diagnosis challenging. Clinical suspicion and specific diagnostic tests, such as serology and polymerase chain reaction (PCR), play a crucial role in identifying the causative pathogens [4].

Treatment of atypical pneumonia typically involves the use of appropriate antibiotics based on the suspected pathogens. Macrolide antibiotics, such as azithromycin or clarithromycin, are commonly prescribed due to their efficacy against Mycoplasma pneumoniae and Chlamydophila pneumoniae. Legionella pneumonia requires specific antibiotic regimens, such as fluoroquinolones or macrolides. Supportive care, including rest, adequate hydration, and antipyretics, is also important for symptom relief and recovery [5].


Atypical pneumonia caused by unconventional pathogens poses unique diagnostic and management challenges. The diverse clinical manifestations and less severe presentation make timely recognition and appropriate treatment crucial for optimal patient outcomes. Increased awareness among healthcare professionals and utilization of specific diagnostic tests are necessary for accurate diagnosis and targeted therapy. Further research is needed to enhance our understanding of these unconventional pathogens and improve strategies for the prevention and management of atypical pneumonia.


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