Opinion Article - Journal of Clinical Nephrology and Therapeutics (2023) Volume 7, Issue 1
An approach to treating renal fibrosis
Department of Nephrology, University of Jilin, Changchun, China
- *Corresponding Author:
- Yue Hu
Department of Nephrology
University of Jilin
Received: 28-Dec-2022, Manuscript No. AACNT-23-85379; Editor assigned: 31-Dec-2022, PreQC No. AACNT-23-85379(PQ); Reviewed: 13-Jan-2023, QC No. AACNT-23-85379; Revised: 19-Jan-2023, Manuscript No. AACNT-23-85379(R); Published: 27-Jan-2023, DOI: 10.35841/aacnt-7.1.133
Citation: Hu Y. An approach to treating renal fibrosis. J Clin Nephrol Ther. 2023; 7(1):133
A safe and effective treatment for renal fibrosis should be developed since there is now no medication that can effectively treat the condition. In addition to its potential to prevent kidney, liver, and cardiac ailments, cordyceps has a number of health benefits including immunoregulatory, anticancer, anti-inflammatory, and antioxidant activities. Additionally, cordyceps has been said to be successful in treating renal fibrosis. The effects of Cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, decrease of extracellular matrix deposition, and fibroblast activation are the main topics of this paper's review of the probable mechanisms of Cordyceps against renal fibrosis. We also talk about relevant meta-analyses and published clinical trials.
Inflammation, Apoptosis, Renal fibrosis.
Acute Kidney Injury (AKI) is a clinical syndrome of acute renal injury brought on by severe illness or following surgery. It has a fatality rate and incidence. It’s complicated pathological damage process includes damage to renal tissues and renal tubules, and it may result in renal fibrosis, which has a negative impact on prognosis. Clinical efforts are mostly focused on treating kidney disease's symptoms, improving postoperative care, and developing alternative therapies. However, the 5-year mortality rate of patients is still more than 50% when AKI has progressed to phases 2-3, requiring a significant amount of social and medical resources. Thus, the search for novel approaches and focused treatment medicines for acute renal injury is crucial .
In tissue recovery and illness treatment, foundational microorganism treatment has turned into a viable elective treatment. Bone marrow mesenchymal immature microorganisms, likewise called pluripotent cells, are capable of self-replication, expansion and separation, and they can likewise be changed and actuated, which have been extensively utilized in quality treatment or immunotherapy. As per clinical explores, Bone marrow mesenchymal immature microorganisms have solid reproducibility and separation capacity, and exogenous transplantation of bone marrow mesenchymal immature microorganisms can reduce the level of renal injury. In treatment of renal injury utilizing bone marrow mesenchymal immature microorganisms, it includes a confounded component, yet intravenous infusion of BMSCs needs to pass endothelial obstruction in blood to arrive at the harmed part, in order to complete the restorative impact. This interaction is extremely muddled, and, without a doubt, not very many BMSCs can arrive at kidney to complete their impact. How to expand the home season of BMSCs in blood? This issue can't be settled by expanding their homing number .
Cordyceps is a parasite that colonizes the hatchlings of moths. It has been utilized for a really long time as a medication in China, Japan, and other Asian nations. It has a few animal types, including Cordyceps sinensis, Cordyceps militaris, and Cordyceps cicadae. Cordyceps has various therapeutic properties or bioactive mixtures, including nucleosides, polysaccharides, cyclodepsipeptides, sterols, alkaloids, and phenolics, which show immunomodulatory, antitumor, mitigating, cancer prevention agent, renoprotective, and different impacts .
Cordyceps has shown possible commitment as an assistant to customary medication to diminish serum creatinine, increment creatinine leeway, decrease proteinuria, and mitigate CKD-related confusions. In view of the organization pharmacology devices that are utilized to explore the atomic system of Cordyceps for the treatment of Diabetic Nephropathy (DN), seven dynamic fixings were screened from Cordyceps, 293 putative objective qualities were recognized, and 85 covering targets matching DN were distinguished as likely helpful targets, for example, cancer rot factor, mitogen-actuated protein kinase 1, epidermal development factor receptor, angiotensin-changing over compound, and Caspase-9. Cordyceps are associated with a fiery reaction, apoptosis, oxidative pressure, insulin obstruction, and other natural cycles through these pathways .
The kidney is an exceptionally metabolically dynamic organ with mitochondria wealthy in oxidative responses and powerless to oxidative pressure harm. Oxidative pressure and irritation cooperate to assume a key part in renal tissue obliteration, irreversible loss of renal capability and movement of RF. Typical cells produce modest quantities of Receptive Oxygen Species (ROS), which assume a significant physiological part. Free extremist searching catalysts and cancer prevention agents keep up with oxygen digestion homeostasis by actuating record factors, directing physiologically dynamic substances and incendiary insusceptibility, and advancing cell multiplication and separation. Oxidative pressure happens when the harmony among ROS and responsive nitrogen species and the cell reinforcement guard framework is upset, or at least, when the development of supportive of oxidants or ROS surpasses the endogenous cancer prevention agent limit .
In this investigation, we discovered that Cordyceps and related compounds could attenuate Radio Frequency (RF) through a variety of routes and targets, but the processes were not independent of one another. Targeting TLR4 could trigger the downstream TGF-/Smad signalling pathway to enhance ECM deposition and fibroblast activity, or it could inhibit inflammation and oxidative stress via NF-B. The control of autophagy, oxidative stress, energy homeostasis, and apoptosis depended on SIRT1 activity. Multitargeting had some benefits, but there was a chance for additional negative impacts as well. Using cordyceps has been linked to toxic adverse effects in both people and animals.
- Chen DD, Xu R, Zhou JY, et al. Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy. Food Funct. 2019;10(8):5102-14.
- Chen J, Hu Y, Chen L, et al. The effect and mechanisms of Fuzheng Huayu formula against chronic liver diseases. Biomed. Pharmacother. 2019;114:108846.
- Chyau CC, Chen CC, Chen JC, et al. Mycelia glycoproteins from Cordyceps sobolifera ameliorate cyclosporine-induced renal tubule dysfunction in rats. J. Ethnopharmacol. 2014;153(3):650-8.
- Darby IA, Hewitson TD. Hypoxia in tissue repair and fibrosis. Cell Tissue Res. 2016;365(3):553-62.
- Das G, Shin HS, Leyva-Gómez G, et al. Cordyceps spp.: A review on its immune-stimulatory and other biological potentials. Front. Pharmacol. 2021:2250.