Journal of Translational Research

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Mini Review - Journal of Translational Research (2022) Volume 6, Issue 5

A systematic scoping review of the factors that contribute to fatigue and potential of non-pharmacological approaches to treating childhood cancer.

Goutam Rout*

Department of Biotechnology, Utkal University, Odisha

Corresponding Author:
Goutam Rout
Department of Biotechnology
Utkal University, Odisha

Received: 01-Sep-2022, Manuscript No. AATR-22-78333; Editor assigned: 02-Sep-2022, Pre QC No. AATR-22-78333 (PQ); Reviewed: 14-Sep-2022, QC No. AATR-22-78333; Revised: 16-Sep-2022, Manuscript No. AATR-22-78333(R); Published: 24-Sep-2022, DOI:10.35841/aatr-6.5.122

Citation: Rout G. A systematic scoping review of the factors that contribute to fatigue and potential of non-pharmacological approaches to treating childhood cancer. Am J Transl Res. 2022;6(5):122

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Therapeutic advancements have improved medication cancer prognosis, shifting the interest towards the management of psychosocial burden and treatment-related morbidity. To critically appraise the procurable proof, we tend to tend to conducted degree umbrella review of metaanalyses of irregular controlled trials on verifying interventions for childhood cancer. The foremost concrete information showed a reduction in procedure-related pain and distress through status. Moreover, exercise improved the purposeful quality of the patients. Regarding medical specialty interventions, most of the meta-analyses regarded the treatment of nausea/vomiting (ondansetron was effective and infections/febrile blood disorder granulocyte-(macrophage) colony-stimulating factors showed benefits.


Cancer, Non-pharmacological, Antecedents, Predictors.


Substantial dissimilarity was detected in thirty one associations. Once and for all, verifying interventions for medication cancer unit being utterly evaluated. However, most of the studies unit small and of moderate quality, light-weight the requirement for added irregular proof thus on extend accuracy in rising the quality of lifespan of patients, survivors and their families, interferes with usual functioning In childhood cancer survivors, CRF can be a pervasive clinical draw back that has got to be addressed, with prevalence rates ranging from zero you want to sixty one [1].

Despite the prevalence of CRF throughout this population, current evidence-based clinical apply tips on the police investigation of CRF in childhood cancer survivors unit discordant regarding administrative unit is in peril of experiencing this symptom highlighted throughout a recent review that alone a pair of the four existing pointers. Hence, as results of its prevalence, there is a comprehensible need to be compelled to settle on targets and elegance adequate interventions to subsume CRF in childhood cancer survivors. To do so, it's a necessity to identify major contributors to CRF throughout this population. Throughout this review, we tend to tend to use the term contributors to elucidate factors, causes, antecedents, predictors, modifiers or maintainers of CRF [2].

We tend to tend to use the term candidate contributor to hunt recommendation from any contributor that was studied whether or not or not it had been found to be significantly associated with CRF or not. A pair of reviews has previously highlighted factors that may play employment at intervals the event of CRF suggested that in childhood cancer survivors, sex, diagnosis, treatment, physical activity level, psychosocial problems and genetic factors unit aspects that may contribute to the event of CRF. Although that specialize in all patients with cancer and not specifically on childhood cancer survivors, has to boot suggested that genetic factors and psychological/ bio behavioral factors (e.g., depression, sleep disturbance, physical activity, physical deconditioning, body mass index, brick and appraisal) would possibly contribute to the event of CRF. To boot better-known treatment-related factors, clinical factors, and demographic factors joined with CRF in childhood cancer [3].

Thus, to date, we tend to tend to do not understand that contributors are studied which are found to be vital. a clear vision of all reportable contributors can facilitate to higher orient intervention ways that by allowing deciding that contributors unit amenable to change. CRF are usually addressed by medical specialty and non-pharmacological interventions. throughout this review, we tend to tend to targeted on the second intervention cluster as a results of to our data, no analysis synthesis presently focuses on the results of non-pharmacological interventions on CRF and its contributors at intervals the particular context of childhood cancer survivorship [4].

Importantly, these three syntheses alone targeted on risk factors (i.e., factors that proof was really strong) so retrieved really restricted proof that was arduous to synthesize. Here, we tend to tend to adopt a broader approach to help future analyzers focus their analysis efforts. We tend to tend to thought-about all contributors to CRF. contrastive with the concept of risk issue, a come-at-able contributor is additionally a component that is alone associated with CRF which a plausible actuating link between the contributor and CRF exists. Our browse is that before limiting analyses to risk factors, it's a necessity to inductively investigate all come-at-able contributors from existing analysis to ultimately synthesize that contributors unit most generally found as vital and thence, modify analysis to bit by bit amass proof. This would possibly lead to eventually distinctive risk factors as a second step. In previous syntheses, the danger factors were pre-established, limited, and sadly rarely studied. The output of the reviews could not inform on potential promising contributors [5].


In the in-treatment childhood cancer patients’ literature, systematic reviews and pointers supporting the effectiveness of non-pharmacological interventions to cut back CRF emerge, with a particular stress on the effectiveness of exercise interventions thus, a recent review on physical activity interventions in in-treatment childhood cancer patients suggests that aerobic, corticifugal and combined physical activity interventions unit significantly effective in reducing CRF in patients, as compared to manage been groups Notably, clinical apply pointers counsel the employment of physical activity, relaxation, and mindfulness to cut back fatigue in in-treatment childhood cancer patients however, we tend to tend to do not perceive if these forms of interventions have utilized in childhood cancer survivors and if they were productive. We tend to tend to do not perceive if there unit various interventions to cut back CRF throughout this population. It’s to boot unclear if these interventions target specific contributors, and whether or not or not all betterknown contributors related to CRF have already been targeted by interventions. There is a demand to cluster and classify procurable studies to specialize in studied associations and missing associations between the factors that drive CRF (contributors) and non-pharmacological interventions.


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