Journal Clinical Psychiatry and Cognitive Psychology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Short Communication - Journal Clinical Psychiatry and Cognitive Psychology (2023) Volume 7, Issue 3

A Comparative Study of antipsychotics in the treatment of schizophrenia

Kasper Liu*

Department of Psychiatric

*Corresponding Author:
Kasper Liu
Department of Psychiatric
Department of Psychiatric, Harvard University, USA

Received:24-Aug-2023,Manuscript No.AACPCP-23- 112118; Editor assigned:28-Aug-2023,PreQC No.AACPCP-23- 112118(PQ); Reviewed:11-Sept-2023,QC No.AACPCP-23- 112118; Revised:16-Sept-2023, Manuscript No.AACPCP-23- 112118(R); Published:22-Sept-2023,DOI: 10.35841/aacpcp-7.3.152

Citation: Liu K. A Comparative Study of antipsychotics in the treatment of schizophrenia. J Clin Psychiatry Cog Psychol. 2023;7(3):152


Schizophrenia is a serious and incapacitating mental illness that affects millions of people worldwide. Antipsychotic drugs, which differ in their pharmacological characteristics and side effect profiles, are the cornerstone of its treatment. The objective of this comparative study is to offer evidence-based guidance on choosing antipsychotic drugs for people with schizophrenia. Symptoms of schizophrenia include hallucinations, delusions, disorganized thinking, and impaired social and vocational performance. Schizophrenia is a complex and crippling mental condition. It poses a serious public health risk because it has an impact on millions of people worldwide.[1].

Antipsychotic drugs are the mainstay of treatment for schizophrenia. They are intended to reduce symptoms, stop relapses, and enhance the general quality of life for those who are affected. However, choosing the best antipsychotic for a particular patient is still difficult because there are several antipsychotic medications available, each with a different pharmacological profile, level of effectiveness, and adverse effect profile.[2].

This comparison study aims to address the urgent need for evidence-based recommendations for selecting the best antipsychotic drug for people with schizophrenia. The objective of the study is to give a thorough comparison of the effectiveness, safety, and tolerability of various antipsychotic medications, taking into account both first-generation (typical) and second-generation (atypical) antipsychotics. This research aims to provide doctors, patients, and policymakers with the most accurate information regarding the best treatment options for schizophrenia, thereby improving clinical outcomes and promoting the well-being of those who are affected.[3].

A complex combination of genetic, neurological, and environmental variables affects the onset and progression of schizophrenia, which is a multifactorial condition. The cornerstone of treatment is antipsychotic medicine because it aids in managing both the positive and, to a lesser extent, the negative symptoms of the condition (such as affective flatness and social withdrawal), such as hallucinations and delusions. Antipsychotics have considerably improved the prognosis for people with schizophrenia, but instead of being based on robust comparative evidence, the choice of medication is frequently made on the basis of clinical experience and the responses of specific patients. The creation and improvement of several types of drugs, such as typical antipsychotics (such as haloperidol and chlorpromazine) and atypical antipsychotics (such as clozapine, olanzapine, and risperidone), have shaped the history of antipsychotic treatment. First-generation antipsychotics have been around for a while, and they are known for their strong antagonistic effects on dopamine D2 receptors.[4].

They are associated with a variety of adverse effects, including as ExtraPyramidal Symptoms (EPS) and tardive dyskinesia, despite being successful in regulating positive symptoms. The 1990s saw the introduction of second-generation antipsychotics, which were created to overcome some of the shortcomings of their forerunners. These medications are thought to have a more favorable side effect profile with relation to EPS and tardive dyskinesia since they often affect serotonin receptors as well as dopamine receptors, which is a broader receptor profile. They do, however, also have metabolic adverse effects like weight gain and a higher risk of diabetes. Clinicians must decide which antipsychotic drug is best for each patient given the variety of antipsychotics on the market. This decision-making process takes into account various elements, including the severity of the symptoms, any potential negative side effects, patient preferences, and cost-effectiveness. In order to successfully direct clinical practice, a thorough and comprehensive evaluation of the various antipsychotic drugs is essential. The effectiveness, safety, and tolerability of several antipsychotic medications, including both first-generation (typical) and second-generation (atypical) antipsychotics, are thoroughly assessed and compared in this study.[5].


It takes into account a variety of elements, such as both effective and ineffective symptom control, extrapyramidal symptoms, metabolic side effects, and unique patient characteristics. In the background section, we discuss how antipsychotic treatment has changed over time, moving from typical antipsychotics with strong dopamine receptor antagonists to atypical antipsychotics with a wider range of receptors. We draw attention to the difficulties faced by doctors when choosing an antipsychotic, which frequently relies on clinical experience rather than comparative research. o carefully evaluate and contrast the effectiveness of various antipsychotic drugs in the treatment of schizophrenia, with an emphasis on how well they work for both good and bad symptoms. Main goals of this investigation to thoroughly assess and compare extrapyramidal symptoms, metabolic side effects, and other adverse events with the safety and tolerability profiles of various antipsychotic drugs. To investigate potential differences in treatment response depending on individual patient characteristics such age, gender, length of illness, and genetic markers. To offer applicable, scientifically-supported advice for choosing antipsychotic drugs to treat schizophrenia that is individualized for each patient's profile. Through this study, we hope to address the urgent need for data-driven advice on selecting the best antipsychotic drug for schizophrenia sufferers. We aim to empower clinicians, patients, and policymakers to make more knowledgeable treatment decisions, ultimately improving the quality of care and enhancing the well-being of those affected by schizophrenia. To this end, we provide insights into the comparative advantages and risks connected with various antipsychotic medications.


  1. Aringhieri S, Carli M, Kolachalam S, et al. Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. Pharmacol Ther. 2018;192:20-41.
  2. Indexed at, Google Scholar,Cross Ref

  3. Baldez DP, Biazus TB, Rabelo-da-Ponte FD, et al. The effect of antipsychotics on the cognitive performance of individuals with psychotic disorders:Network meta-analyses of randomized controlled trialsNeurosci Biobehav Rev. 2021;126:265-75.
  4. Indexed at, Google Scholar,Cross Ref

  5. Bhat AA, Gupta G, Afzal O,et al. Neuropharmacological effect of risperidone: From chemistry to medicineChem Biol Interact. 2022:110296.
  6. Indexed at, Google Scholar,Cross Ref

  7. Biswas AB, Furniss F.Cognitive phenotype and psychiatric disorder in 22q11. 2 deletion syndrome: A review.Res. Dev. Disabil.2016;53:242-57.
  8. Indexed at, Google Scholar,Cross Ref

  9. Boyenle ID, Oyedele AK, Ogunlana AT, et al.Targeting the mitochondrial permeability transition pore for drug discovery: Challenges and opportunities.Mitochondrion. 2022;63:57-71.
  10. Indexed at, Google Scholar,Cross Ref

Get the App