Asian Journal of Biomedical and Pharmaceutical Sciences

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- Asian Journal of Biomedical and Pharmaceutical Sciences (2014) Volume 4, Issue 35

Spectroscopic and Viscositic Studies on the Interaction of Solifenacin Succinate with DNA

The interaction of native calf thymus DNA (ctDNA) with solifenacin succinate (SFS) was investigated under simulated physiological conditions by multi-spectroscopic techniques and viscometric measurements. It concluded that SFS could intercalate into the base pairs of ctDNA, and the fluorescence quenching by ctDNA was static quenching type. Thermodynamic parameters calculated suggested that the binding of SFS to ctDNA was mainly driven by hydrophobic interactions. Furthermore, the relative viscosity of ctDNA increased with the addition of SFS, which confirmed the intercalation mode.

Author(s): Gowda BG, Mallappa M, Mahesh RT, Hadimani CC

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