Research Article - Journal of Clinical and Bioanalytical Chemistry (2021) Volume 5, Issue 4
Spectrophotometric determination of ziprasidonehydrochloride (zpn), 5-[2-(4-benzo [d] isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1, 3-dihydindol-2-one hydrochloride using gold (III).
Ziprasidone hydrochloride (ZPN) forms a pink-coloured complex among gold (III) in an aqueous solution at pH 5.0. The ZPN complex show the absorption utmost at 600 nm and the BeerLambert’s law is obeyed in the range of 5.0-60.0 µg/ml. The pragmatic formula and molecular mass of Ziprasidone hydrochloride (ZPN), 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3- dihydro-indol-2-one hydrochlorideare C21H22Cl2N4OS and 448.94 correspondingly. In the present work, it was in employment for the receptive spectrophotometric determination of ZPN. The molar absorptivity and sandal’s sensitivity were found to be 7.48 × 103 mol-1 cm-1 and 0.0604 µg/cm2 correspondingly. The complex shows 1:1 [ZPN: Au (III)] stoichiometry with a steadiness constant of 2.54 × 104. The effect of interference of various amounts of excipients has been studied. In addition to zero- order, first derivative spectrophotometrAuthor(s): A Mohamed Sikkander*, Rafi SK