Mini Review - Journal of Clinical Research and Pharmacy (2022) Volume 5, Issue 5
Scientific progresses and hones of chemotherapy resistance and drug technology in tongue cancers.
The primary target of metronomic chemotherapy was originally identified as endothelial cells supporting the tumour vasculature, and not the tumour cells themselves, consistent with the emerging concept of cancer as a systemic disease involving both tumour cells and their microenvironment. While anti-angiogenesis is an important mechanism of action of metronomic chemotherapy, other mechanisms, including activation of anti-tumour immunity and a decrease in acquired therapeutic resistance, have also been identified. Author(s): Thomas Mulder*