Abstract - Journal of Clinical Research and Pharmacy (2021) Volume 4, Issue 2
Microwave Synthesis, Characterization, Biological Activity of N- (p-Chlorophenyl)-N'-Benzoyl Thiourea and its Complexes
A derivative of thiourea ligand N-(p-chlorophenyl)-N'-Benzoyl thiourea (PCBT) in equimolar ratio 1:1 and its transition metal complexes CoII, NiII , CuII and ZnII were synthesized by microwave (green chemistry). The structure of ligand and its complexes have been characterized by using elemental analysis, mass Spectroscopy, FT-IR, UV-Vis., 1HNMR and 13CNMR. The geometry of the proposed structures of the chelates based on their electronic spectra, electron spin resonance (ESR) and magnetic susceptibility. The stability of complexes was studied by TGA analysis (Thermal studies). The free derivative thiourea ligand (PCBT) and its complexes were studied for antimicrobial and antifungal activity.
Author(s): Ali MH1,Â Zaghloul IE2Â andÂ Khalid MW3*