Asian Journal of Biomedical and Pharmaceutical Sciences

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Editorial - Asian Journal of Biomedical and Pharmaceutical Sciences (2021) Volume 11, Issue 80

Microinjection of Reelin into the mPFC cures memory debilitation in mice

Reelin, a huge extracellular grid protein, assists with directing neuronal versatility and intellectual capacity. A few investigations have shown that Reelin brokenness, coming about because of variables, for example, transformations in quality RELN or low Reelin articulation, is related with schizophrenia (SCZ). We recently announced that microinjection of Reelin into cerebral ventricle forestalls phencyclidine-initiated intellectual and tangible engine gating shortages. Nonetheless, it stays hazy whether and how Reelin improves conduct anomalies in the creature model of SCZ. In the current review, we assessed the impact of recombinant Reelin microinjection into the average prefrontal cortex (mPFC) on unusual practices prompted by MK-801, a N-methyl-D-aspartate receptor bad guy.

Author(s): Ujjwal Kumar De

Abstract Full Text PDF

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