Journal of Clinical Immunology Research

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Special Issue Article - Journal of Clinical Immunology Research (2020) Volume 0, Issue 0


HPV is a viral infection caused by Human Papillomavirus, a DNA virus from the Papillomaviridae family. Hiv-infected women have a high prevalence of Human Papillomavirus (HPV) infection and are more likely to be infected with HPV type 16 which is considered high-risk and have potential for progressing to cervical cancer. The objective of this study is to determine the prevalence of Human Papillomavirus type 16 among the Hiv positive women that attend Aminu Kano Teaching Hospital, Kano. Also, the impact of CD4 levels on the HIV-infected women. A totalof 86 HIV positive women were enrolled in this study. Pap smear were carried out on the 86 HIV-positive women, papanicolaus staining method was used to detect cell abnormalities in the cervix, the test result showed that, low squamous intra-epithelial lesion (LSIL) were 17 (19.8%), atypical squamous cell-high squamous intra-epithelial lesion (ASC-HSIL cannot be excluded) were 11 (12.8%), negative with inflammation were 38 (44.2%), and negative smear were 20 (23.3%). The 28 samples that have cell abnormalities,their serum samples were collected and screened for HPV type 16 IgG Antibody using ELISA. The  result showed that 6 (21.4%) were positive for HPV type 16. A questionnaire was administered to collect relevant information such as CD4 levels, viral loads, etc. Data generated were analyzed using SPSS software version 20. There were no significance difference (P>0.05). In conclusion, this study discovered high prevalence of cell abnormalities caused by human Papillomavirus type 16 among women living with HIV- infection. And there is a great impact on CD4, as the HPV negative have a higher CD4 count than HPV positive. Finally, it is recommended that women living with HIV should be screened annually for HPV infection and cervical cancer, for early detection of pre-cancerous cells and there by prevent the occurrence of invasive cervical cancer
Author(s): Usman Aliyu Dutsinma

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