- Asian Journal of Biomedical and Pharmaceutical Sciences (2011) Volume 1, Issue 2

Formulation development and dissolution enhancement of Compeba-400 (Metronidazole-400) tablet

The reason of this study is to diminish or entirely end of binding and capping dilemma of metronidazole tablet. Metronidazole is an antiemetic and prokinetic drug used in the management of motion sickness in adults and children. As meticulousness of dosing and patient’s compliance become imperative prerequisite for quick relief from motion sickness. Fast dispersible tablets disintegrate either rapidly in water, to form a stabilized suspension, or disperse instantaneously in the mouth to be swallowed without the aid of waters. A direct compression technique was used to prepare these types of tablets using diverse super disintegrants. An endeavor was made in the current work to formulation development and enhancement dissolution of metronidazole (COMPEBA-400) tablets. This research work is also investigated a new dosage form of metronidazole with lofty dissolution rate and squat cost. To afford the patients with the most conventional mode of administration, there was a stipulation to build up tablet dosage form, chiefly one that disintegrants and dissolves/disperses in body fluid administered with water. Both the derivatives Methyl Chloride and Isopropyl alcohol have tremendous film forming and coating properties. By using MCC at the place of lactose & sugar we can dwindle the tablet price and augment dissolution rate. The compressed tablet is the most accepted dosage form in use these days. About two-thirds of all prescriptions are dispensed as solid dosage forms, and half of these are compressed tablets. By using CCS in lubrication we can amplify the dissolution rate of tablet because CCS helps to suspend the tablet rapidly from edge and centre of the tablet. Hefty amount of binder like as starch, gelatin, glucose and polyvinylpyrrolidone (PVP) in paste thwart to the tablet from capping. No significant changes were pragmatic when drug content were analyzed after one month stability testing.

Author(s): Kapoor D, Rajora A, Saini V

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