Research Article - Current Trends in Cardiology (2025) Volume 9, Issue 2

Evaluation of MR-pro-ANP and NT-pro-BNP in assessing cardiovascular risk among diabetic individuals

Cardiovascular Disease (CVD) remains the leading cause of morbidity and mortality among individuals with diabetes mellitus. The early detection and management of cardiovascular risk in this population are crucial for improving clinical outcomes. This study aims to evaluate the utility of Mid Regional pro-Atrial Natriuretic Peptide (MR-pro-ANP) and N-Terminal pro-Brain Natriuretic Peptide (NT-pro-BNP) as biomarkers for assessing cardiovascular risk among diabetic individuals. A cross-sectional study was conducted, enrolling 300 diabetic patients from a tertiary care hospital. Participants underwent comprehensive cardiovascular risk assessments, including detailed medical history, physical examination, and laboratory investigations. Blood samples were collected to measure levels of MR-pro-ANP and NT-pro-BNP, alongside conventional cardiovascular risk factors such as lipid profile, HbA1c, and C-Reactive Protein (CRP). The results demonstrated that both MR-pro-ANP and NT-pro-BNP levels were significantly elevated in diabetic patients with established cardiovascular disease compared to those without. Furthermore, elevated levels of these biomarkers correlated strongly with traditional risk factors, including hypertension, dyslipidemia, and poor glycemic control. Multivariate analysis revealed that MR-pro ANP and NT-pro-BNP were independent predictors of cardiovascular events, with NT-pro-BNP showing a slightly higher predictive value. Our findings suggest that MR-pro-ANP and NT-pro-BNP are valuable biomarkers for identifying diabetic patients at high risk of cardiovascular complications. The incorporation of these biomarkers into routine clinical practice could enhance risk stratification and guide targeted interventions to mitigate cardiovascular risk in this vulnerable population. Further longitudinal studies are warranted to validate these findings and establish the long-term prognostic significance of MR-pro-ANP and NT pro-BNP in diabetic individuals. In conclusion, the evaluation of MR-pro-ANP and NT-pro-BNP offers a promising approach for the early detection and management of cardiovascular risk among diabetic patients, potentially improving clinical outcomes and reducing the burden of cardiovascular disease in this high-risk group.

Author(s):

Daniel Sundar Singh, Anand B Pithadia, Lavanya S*

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