Asian Journal of Biomedical and Pharmaceutical Sciences

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- Asian Journal of Biomedical and Pharmaceutical Sciences (2013) Volume 3, Issue 23

Development of new Analytical Methods and their Validation for the Determination of Tizanidine Hydrochloride in Bulk and Marketed Formulations

Tizanidine Hydrochloride in presence of acidic medium reacts with excess amount of potassium bromide-bromate and unreacted potassium bromidebromate react with malachite green to produce green colour.The final stock solution was made to produce 100μg/ml with distilled water. The λmaxwas found to be 617nm for assay. The linearity was found in concentration range of 10-30μg/ml. The correlation coefficient was found 0.999. The regression equation was found as Y=0.009x + 0.002. The method was validated according to ICH Guidelines.

Author(s): Sumit Saparia, Padmavathi P. Prabhu, Dr. E.V.S Subrahmanyam, Jignesh Kaneria, Sagar Bechara, Dr A.R.Shabaraya

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