Hematology and Blood Disorders

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Research Article - Hematology and Blood Disorders (2021) Volume 4, Issue 4

Association of serum ferritin and hba1c level with diabetes complications in diabetes type-2 mellitus in Rajshahi medical college hospital, Rajshahi, Bangladesh.

Introduction: Diabetes is a metabolic disorder characterized by hyperglycaemia and raised HbA1c. Serum Ferritin is an acute phase protein and it is a marker of iron stores in the body. Excess iron damages ?-cells of pancreas due to oxidative stress contributing to pathogenesis of diabetes mellitus. The complications of diabetes mellitus are influenced not only by the duration of the diabetes mellitus but also by the average level of blood glucose along with glycated haemoglobin. Raised serum ferritin may possibly be related to the occurrence of longterm complications of diabetes, both microvascular and macrovascular. Objective: The aim of this study is to establish a correlation between serum ferritin and glycated haemoglobin levels in type 2 diabetes mellitus patients. Materials and Methods: This study was done in the department of Medicine, Rajshahi Medical College, and Rajshahi, Bangladesh done from July-2018 to Jun-2019. The study comprised of total 100 subjects. Blood samples were analysed for Ferritin, HBA1C and fasting plasma glucose. Domain OCT was performed using CIRRUS HD OCT after pupillary dilatation. Signal strength of 6 or higher was considered acceptable. Results: Serum ferritin was significantly higher in diabetic patients when compared with control group (p<0.001). Serum ferritin is positively correlated with HbA1c and also serum ferritin had a positive correlation with increasing duration of diabetes. Conclusion: Serum ferritin and HBA1C level were elevated in patients with type 2 diabetes mellitus when compared to healthy individuals and it indicates that serum ferritin can be used as a marker for glycemic control in diabetic patients. Author(s): Jamil AM, Shirin R, Hoque A, Rahman K, Khan MMR, Uddin SK.MA, Saha MK, Tareq MZ, Barai LC

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