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Review Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2019) Volume 9, Issue 68
A Review of Ethnomedicinal, Phytochemical, Pharmacological and Toxicological Aspects of Eupatorium adenophorum Spreng
Eupatorium adenophorum Spreng belonging to the family Asteraceae have traditionally been used as folklore medicine across the world. In traditional system of medicine, it is regarded as antiinflammatory, antimicrobial, antiseptic, analgesic, antipyretic, blood and coagulant. The present review summarizes the updated information concerning the ethnomedicinal, phytochemical, pharmacological and toxicological aspects of E. adenophorum. A thorough bibliographic investigation was carried out by analyzing worldwide accepted scientific data base (Pub Med, Google Scholar, Scopus SciFinder, and Web of Science), thesis, recognized books and other accessible literature from 1980 to 2017. The phytochemical and pharmacological studies demonstrated that E. adenophorum possess a wide spectrum of pharmacological activities, such as anti-inflammatory, analgesic, antipyretic, antioxidant, antibacterial, antifungal, antitumor, antioxidant, antiseptic and cytotoxic activities which could be attributed to the presence of array of phytochemicals of various groups including terpenoids, phytosterols, alkaloids, flavonoids, phenolic acids, coumarins, phenylpropanoids, sesquiterpene lactones, polysaccharides, and essential oil. Modern phytochemical and pharmacological studies have led to the isolation and characterization of a number of bioactive compounds from different parts of the plant as well as validation of its traditional medicinal uses. However, certain known toxic effects of E. adenophorum demand a thorough study of long-term toxicity and other toxicological aspects. Furthermore, the relationship of molecular structures of compounds of E. adenophorum with its various pharmacological activities needs further study and confirmation.
Author(s): YC Tripathi, Nidhi Saini, Nishat Anjum, Praveen Kumar Verma