Research Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2020) Volume 10, Issue 71
A multifunctional Streptomyces maritimus SACC-152 isolated from Andaman and Nicobar Islands, India.
A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was
investigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological
and molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus.
Bioactive metabolites from the strain SACC-152 were produced by submerged fermentation and
extracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum
of antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage
(LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug
sensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed
promising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68 Author(s): Manigundan Kaari, Jerrine Joseph*, Sivarajan Anbalman, Vignesh Angamuthu, Ayswarya Sreenivasan, Gopikrishnan Venugopal, Radhakrishnan Manikkam, Balagurunathan Ramasamy, WilsonAruni
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