Research Article - Biomedical Research (2016) Volume 0, Issue 0

## Automatic detection of lung cancer nodules by employing intelligent fuzzy cmeans and support vector machine

**Sakthivel K**

^{1*}, Jayanthiladevi A^{2}, Kavitha C^{3}^{1}Department of Computer Science and Engineering, K S Rangasamy College of Technology, Tamil Nadu, India

^{2}Department of Computer Applications, Jain University, Bangalore, Karnataka, India

^{3}Department of Computer Science, Thiruvalluvar Government Arts College, Tamil Nadu, India

- *Corresponding Author:
- Sakthivel K

Department of Computer Science and Engineering

K S Rangasamy College of Technology

Tamil Nadu

India

**Accepted date:** August 11, 2016

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### Abstract

Segmentation is an essential step in image systems for the accurate lung disease diagnosis, since it delimits lung structures in Computerised Tomography (CT) images. Indeed, image processing techniques can help computer diagnosis if lung region is accurately obtained. A conventional fuzzy cmeans clustering algorithm that has been implemented for segmentation of the Computerised Tomography (CT) lung images still suffers with low convergence rate, getting stuck in the local minima and vulnerable to initialization sensitivity. The proposed system presents an intelligent and dynamic approach called Intelligent Fuzzy C-Means (IFCM) to segment the lung nodules automatically and classify the lung nodules effectively using support vector machine classifier. This approach uses the capability of firefly search to find optimal initial cluster centers for the Fuzzy C-Means (FCM) and thus improve the segmentation accuracy. The features are extracted using fused tamura and haralick features after segmentation. These features are trained using different kernels of support vector machine for automatic detection of lung nodules as benign or malignant. The performance of support vector machine is evaluated by computing different measures from confusion matrix.

## Keywords

Segmentation, Firefly search, Fuzzy c-means, Support vector machine, Confusion matrix.

## Introduction

Computer-Aided Design (CAD) systems for medical images typically involve the steps of segmentation of the image and classification of that segmented area. Various algorithms from different authors can be found for medical image segmentation such as thresholding, edge based and region based clustering. These methods may be effective for specific types of disease; segmentation of lungs is always a challenging problem due to changes in pathology in the parenchyma area, or in shape and anatomic connection to neighbouring pulmonary structures, such as blood vessels or pleura.

It could be a great clinical importance if patient's chance of survival is increased by an effective Computer-Aided Design (CAD) system [1]. The systems are developed to support the process of distinguishing malignant with benign lesions. The systems need to improve both the sensitivity and specificity in order to be successful for clinical use. Computer-Aided Design (CAD) methods may use features extracted either by the computer or by the radiologist [2]. For interpreting instantaneous data, radiologists employ many radiographic images and computer analysis is needed for determining the significant features.

Fuzzy c-means algorithm is popular algorithm for robust lung image segmentation. The fuzzy c-means algorithm attempts to partition a finite collection of n elements into a collection of c fuzzy clusters with respect to some given criterion. Many metaheuristic search algorithms have been hybridized with the fuzzy c-means algorithm to find optimal cluster centers. These algorithms explore the entire search space in the problem to determine possible solutions. These algorithms include bee optimization, harmony search, the ant colony algorithm, simulated annealing, the genetic algorithm, tabu search, the firefly algorithm and particle swarm. In this research work the data is in the form of Computer Tomography (CT) images of the lung and hence image analysis is done to perform diagnosis. The segmentation of such image is done by using an intelligent and dynamic approach called Intelligent Fuzzy CMeans with firefly search (IFCM) and classified effectively using support vector machine.

**Related works**

Image processing plays a vital role in diagnosis of diseases using automatic detection of lung nodules based on images. This research focuses on Computer-Aided Design (CAD) systems for diagnosis of lung cancer. As with any system employing image analysis and image understanding, segmentation is one of the primary processes in a Computer- Aided Design (CAD) system that works with images. Segmentation of lung cancer is a challenging task [3]. The Region Of Interest (ROIs) can be extracted only if the lungs are correctly segmented [4]. If the segmentation is incorrect, it may increase the false positives and false negatives thereby affecting the diagnostic accuracy of the system. Hence, it is important to use a robust and reliable technique for segmentation.

The use of Artificial Intelligence (AI) in diagnostic expert systems aims at making the systems to mimic the decisionmaking process of human experts. However, such systems can be used only to provide a “second opinion” to the physicians in improving diagnostic accuracy and cannot be considered as a replacement for a physician. Artificial Intelligence (AI) techniques that are most frequently used in Computer-Aided Design (CAD) systems in the literature are Fuzzy logic, Genetic Algorithms, Neural Networks and ensemble approaches.

Image segmentation is more crucial part in obtaining information from the medical images. It is used for detecting the threatening diseases in medical field which lead to death. The lungs segmentation is a challenging problem due to the need of different scanners and scanning protocols for scanning the homogeneities in the lung region, pulmonary structures of similar densities such as arteries, veins, bronchi, and bronchioles [5]. The segmentation of lung regions from Computer Tomography (CT) images and chest radiographs by a particular technique can be addressed in terms of accuracy, processing time, and automation level. The major classification of lung segmentation techniques [6] are divided in to four categories: methods based on signal thresholding, deformable boundaries, shape models, edge based and region based.

Among all the segmentation methodologies mentioned in the literature, fuzzy c-means produce a robust segmentation results. But, the initial cluster centroid values and number of clusters should be given as input for fuzzy c-means. This limitation prevents traditional fuzzy c-means to become more popular in image segmentation. Initial cluster center and number of cluster could be dynamically generated using a popular metaheuristic search algorithm called firefly search algorithm. The hybridization of Intelligent Fuzzy C-Means with firefly search (IFCM) for segmenting the lung Computer Tomography (CT) images produces robust segmentation. Support vector machine classifier is superior among all other classifiers mentioned in the literature [7]. Hence, this research uses support vector machine for effective classification of lung nodules.

## Materials and Methods

The proposed scenario considered the automatic detection of lung cancer nodules and classification of lung cancer nodules which is acquired from computed tomography. The data is collected from the histology banks and samples are sorted across thousands of patients. These image data is pre-processed to extract the lung region alone. The Region Of Interest (ROI) is determined by using segmentation algorithm and features are extracted for classifying the cancerous or non-cancerous regions.

The proposed computer aided diagnosis systems comprises of four phases for early detection of lung cancer and are as follows:

Phase 1: Image denoising.

Phase 2: Segmentation of lung region and Region Of Interest (ROIs).

Phase 3: Feature extraction from the segmented region.

Phase 4: Classification of malignant and benign nodules.

**Figure 1** show the proposed system implemented with all the
phases of Computer-Aided Design (CAD) system. In the initial
phase of this Computer-Aided Design (CAD) method,
Computer Tomography (CT) lung image is denoised using
median filter. Next image is segmented using Intelligent Fuzzy
C-Means (IFCM) and segmentation quality is validated. After
segmentation tamura and haralick texture features are extracted
to classify benign or malignant using support vector machine
which automatically detect lung cancer nodules [8]. Finally the
performance is evaluated using confusion matrix.

Segmentation by proposed Intelligent Fuzzy C-means (IFCM) algorithm: fuzzy clustering is the process of assigning the membership value and using them to assign elements to one or more clusters [9]. The commonly used fuzzy method for clustering is Fuzzy C-Means (FCM) [10]. The aim of the objective function of Fuzzy C-Means (FCM) is to find the cluster centers and to produce class membership matrix, which designates a membership to a data point, depending on the relativity of the data point to a particular class when compared to other classes. The performance of the firefly algorithm in terms of obtaining near-optimal cluster centers values in the initialization phase in the Fuzzy C-Means (FCM) algorithm is investigated [11]. A clustering approach based on Fuzzy CMeans is proposed [12]. The proposed clustering method consists of two phases:

In order to determine the optimal cluster centers, firefly
inspects the search space of the given dataset and then the
values of the cluster centers will be obtained using the firefly algorithm. The pseudo code for the proposed Intelligent Fuzzy
C-Means (IFCM) algorithm is given below and obtained result
is shown in **Figure 2**.

**Phase I**

Begin

Initialize the parameters of the firefly algorithms:

• Fireflies number (n).

• Maximum number of generations (Max-generation, iterations,).

• β_{0}, α and γ

Generate the initial population (n initial solutions) of fireflies Xi = (i=1, 2, 3, …, n)

The intensity of the light at will be determined using the objective function value F (x).

Determine the absorption (assimilation) coefficient γ.

While (m < Maxgeneration)

For i=1: n//n-number of all fireflies

For j=1: n//n-number of all fireflies

If (Ij>Ii)

Move firefly i towards j in d-dimension

End if

Get attractiveness, which differs with distance r via exp [- γ r]

Calculate the new solutions and update light intensity

End for j

End for i

**Phase II**

Initialize fuzzy c-means cluster center by new solution of firefly algorithm

For t=to max Iterations do

Update the membership matrix u_{ij}

Calculate the new cluster centers v_{ij}

Calculate the new objective function J_{m}

If (abs (U^{(k+1)}-U^{(k)}< ε) then

Break;

Else

U^{(k+1)}-U^{(k)}

End if

End for

End

**Segmentation accuracy**

The segmentation accuracy A_{s} [13] is calculated using
Equation 1 to evaluate the quality of the segmented lung
computer tomography image using Intelligent Fuzzy C-Means
(IFCM) with firefly search

→(1)

Where S_{prop} and O_{prop} is defined as

S_{prop} = (Solidity+Area+Perimeter) segmented

O_{prop} = (Solidity+Area+Perimeter) unsegmented

The segmentation accuracy A_{s} is computed and the results are
shown in **Table 1** and it is observed that proposed Intelligent
Fuzzy C-Means (IFCM) performs better segmentation.

Segmentation methodologies | Accuracy (%) |
---|---|

Fuzzy Possibilistic C- Means (FPCM) | 82.67 |

Proposed Intelligent Fuzzy C-Means (IFCM) | 96.63 |

**Table 1:** Segmentation accuracy for Fuzzy Possibilistic C- Means
(FPCM) and Proposed Intelligent Fuzzy C-Means (IFCM).

**Automatic detection of lung cancer nodules using
support vector machine**

Texture features are important which is used for identifying objects or Regions Of Interest (ROIs) in a lung computer tomography image. Haralick and Tamura texture features are extracted from the segmented region. Both features will be fused to train the binary support vector machine classifier with the assumption that label 1 belongs to malignant and label 0 belongs to benign. Three kernels such as linear kernel, polynomial kernel and radial basis function are used to construct support vector machine classifier [14]. The most used kernel function for support vector machine is Radial Basis Function (RBF) because of their localized and finite responses across the entire range of real x-axis. The classification accuracy of Radial Basis Function (RBF) kernel was high; also, the bias value and the error rate of Radial Basis Function (RBF) kernel were small when compared to other kernels. After the learning process is completed by providing several conditions, the proposed technique would be able to detect the presence of cancer in the lung region automatically.

## Performance Evaluation

A total of 400 images are considered in this work of which 200
belong to benign and the rest belong to malignant cases. The
input datasets are grouped into two; a training set and a testing
set with 200 datasets each. The performance of the proposed
Computer-Aided Design (CAD) system is evaluated using the
following parameters based upon the confusion matrix as
shown in **Table 2**.

98 (TP) | 3 (FP) |

02 (FN) | 97 (TN) |

**Table 2:** Confusion matrix.

Accuracy (ACC)

Sensitivity (SEN)

Specificity (SPE)

Positive Predictive Value (PPV)

Negative Predictive Value (NPV)

F-Score (FS)

Accuracy is a measure that rates the overall effectiveness of the
system. Referring to **Table 3**, the sensitivity and specificity of
Radial Basis Function (RBF) kernel are 98% and 97%
respectively. The false positive proportion using Radial Basis
Function (RBF) kernel is 3% and the false negative proportion
using Radial Basis Function (RBF) kernel is 2%. False positive
and false negative proportions are the complements of
sensitivity and specificity respectively.

Measures | Linear (%) | Polynomial (%) | RBF (%) |
---|---|---|---|

Sensitivity | 92 | 94 | 98 |

Specificity | 87 | 93 | 97 |

Accuracy | 89.5 | 93.5 | 97.6 |

PPV | 87.62 | 93.07 | 97.03 |

NPV | 91.58 | 93.94 | 97.98 |

F-Score | 89.75 | 93.53 | 97.51 |

**Table 3:** Performance measures obtained using different kernels of
support vector machine.

The positive predictive value of radial basis function kernel is
97.03% which indicates the proportion of the patients with
positive test results who are correctly diagnosed and it is higher
compared to the other methods. The F-score is a measure of a
test's accuracy. The F-Score can be interpreted as a weighted
average of the precision and recall and takes its best value as 1
and worst score as 0. The F-score of radial basis function
kernel is closer to 1. The accuracy obtained using the radial
basis function kernel is 97.6% which is higher than that those
obtained using other kernels. **Table 3** shows the overall
performance measures of linear, polynomial and radial basis
function kernels of support vector machine. From this, it is
inferred that support vector machine radial basis function
kernel outperforms the other two kernels.

Automated Computer-Aided Design (CAD) systems are useful
for radiologists for detection and diagnose of lung cancer from
computer tomography images. **Table 4** shows the comparative
results of various existing Computer-Aided Design (CAD)
systems [13,15] with the proposed system. The proposed
system outperforms the state-of-art Computer-Aided Design
(CAD) systems with the accuracy of 97.6% and the average
false positive ratio of 0.03%. It is clear that, when sensitivity
and specificity increases, the presence of the malignant and
benign nodules are classified correctly. The accuracy of the
Computer-Aided Design (CAD) system will also improve. If
the sensitivity and specificity decreases, the accuracy of the
Computer-Aided Design (CAD) system will decrease which
leads to misclassification of malignant and benign nodules.
From the observation, it is proved that the proposed Computer-
Aided Design (CAD) system performs better when compared
with the other state-of-art Computer-Aided Design (CAD)
systems.

Computer-Aided Design (CAD) Systems | Sensitivity (%) | Specificity (%) | Accuracy (%) | FP rate (%) |
---|---|---|---|---|

Mabrouk et al. [13] | 94.1 | 95 | 94.9 | 0.05 |

Ganesh et al. [15] | 96.15 | 94.13 | 95.56 | 0.05 |

Proposed Intelligent Fuzzy C-Means (IFCM) | 98 | 97 | 97.6 | 0.03 |

**Table 4:** Performance comparison of proposed system with existing
computer-aided design systems.

## Conclusion

In this study, intelligent fuzzy-c means algorithm have been presented for segmenting the computer tomography lung nodules. Initially the images are denoised and applied with the proposed segmentation method. The segmentation accuracy is better when compared with the Fuzzy Probabilistic C-Means (FPCM). A support vector machine classifier is constructed and trained using fused texture features which are extracted from segmented region. The performances are evaluated and the accuracy achieved is 97.6% with the average false positive ratio of 0.03%. From the observation, it is proved that the proposed Computer-Aided Design (CAD) system employing intelligent fuzzy-c means and support vector machine performs better when compared with the other state-of-art Computer- Aided Design (CAD) systems.

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