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Young type 1 diabetes mellitus (T1DM) patient with glucose-6-phosphate dehydrogenase deficiency occurring hemolysis: A case report

Hemolysis during type 1 diabetes mellitus treatment in patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency has been reported, but the underlying pathogenesis is not fully clarified. In this report, we described a girl in whom hemolysis occurred after Diabetic Ketoacidosis (DKA) treatment. Determination of G6PD activity and gene analysis confirmed the diagnosis of G6PD deficiency. We suppose that reducing of G6PD activity by hyperglycemia and decreased source of glucose in the pentose phosphate pathway because of decrease glucose levels may be the mechanism of hemolysis during DKA treatment.

Author(s): Lele Hou, Shaofen Lin, Zhe Meng, Lina Zhang, Zulin Liu, Xiangyang Luo, Liyang Liang