Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 18

XRCC1 gene rs25487, rs1799782 polymorphisms do not influence the susceptibility of CAD

Background: Two meta-analyses assessed the association between X-Ray Repair Cross Complementing 1 (XRCC1) gene polymorphisms and Coronary Artery Disease (CAD) risk. However, these two metaanalyses all included the studies without Hardy-Weinberg equilibrium (HWE). Therefore, their results were not reliable.

Methods: PubMed, EMBASE, MEDLINE, and the Cochrane Library were searched up to May 2017. Odds Ratios (OR) and 95% Confidence Interval (CI) were evaluated to determine the strength.

Results: Five case-control studies with 1715 cases and 1520 controls were included in this meta-analysis. A significant association was not found between XRCC1 rs25487 polymorphism and CAD risk (OR=0.93; 95% CI, 0.72-1.21; P=0.61). No significant association was found between XRCC1 rs25487 polymorphism and CAD risk in Caucasian (OR=0.93; 95% CI, 0.63-1.39; P=0.74) and Asian (OR=0.93; 95% CI, 0.50-1.75; P=0.83). A significant association was also not found between XRCC1 rs1799782 polymorphism and CAD risk (OR=1.07; 95% CI, 0.92-1.25; P=0.39). In the Caucasian subgroup, no significant association was observed (OR=1.07; 95% CI, 0.92-1.25; P=0.39).

Conclusions: This meta-analysis suggested that XRCC1 gene rs25487, rs1799782 polymorphisms were not associated with CAD risk.

Author(s): Ying-Nan Wang, De-Wei Wang, Lei Gao, Shi-Yong Wu, Dong-Yin Zhang, Shu Qin

Abstract Full Text PDF