Biomedical Research

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Wound healing process and related laboratory indexes in patients with type 2 diabetes mellitus after hyperbaric oxygen intervention

Objective: To investigate the effect of hyperbaric oxygen intervention on chronic wound healing in type 2 diabetes mellitus, and its influence on serum inflammatory factors, oxidative stress factors and angiogenesis related factors.

Methods: Totally 78 type 2 diabetes mellitus patients with chronic wounds treated in our hospital were randomly divided into 2 groups, 39 cases in each group. The control group was treated with routine surgical wound intervention, while the observation group receiving hyperbaric oxygen therapy combined with routine surgical wound intervention. The trend of the change of wound area were compared between the 2 groups. C- reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), superoxide dismutase-1 (SOD-1), malondialdehyde (MDA), vascular endothelial growth factor (VEGF) and angiopoietin II (Ang-2) in peripheral blood before and after treatment in 2 groups were observed.

Results: In the observation group, the wound area at 2~5 weeks during treatment were significantly smaller than those in the control group (P<0.05). Before treatment, CRP, IL-6, SOD-1, TNF-α, MDA, VEGF and Ang-2 in 2 groups were close (P>0.05), in 30 days after treatment, CRP, IL-6, TNF-α and MDA in the treatment group were much less than those in the control group, SOD-1, VEGF and Ang-2 in the treatment group were much more than those in the control group, the differences were statistically significant (P<0.05).

Conclusion: Hyperbaric oxygen intervention can promote the healing of chronic wound in type 2 diabetes mellitus, which may be related to the inhibition of CRP, TNF-α, IL-6, MDA, and the promotion of SOD-1, VEGF and Ang-2.

Author(s): Na Li, Xiang-En Meng, Da-Zhi Guo, Dan-Feng Fan, Shu-Yi Pan