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Vector-based siRNA delivery strategies for high-throughput screening of novel target genes

Application of siRNA in high-throughput fashion is still in its early phase although the principle has been established for three years. In this review, we outline the different vector-based siRNA delivery platforms as well as resources that are becoming available for high-throughput applications, and some initial outcomes of vector siRNA high-throughput screening efforts using vector encoded siRNA. It is expected that further improvement of the siRNA technology and availability of the siRNA resources will help to materialize the potential of siRNA for functional genomics and drug target validation.

Author(s): Meihong Chen, Quan Du, Hong-Yan Zhang, Claes Wahlestedt and Zicai Liang*