This study aims to investigate the clinical efficacy of integrated Traditional Chinese Medicine and Western Medicine (TCM-WM) in treatment of late-onset epilepsy after cerebral hemorrhage. 60 patients with late-onset epilepsy after cerebral hemorrhage were divided into control group and TCMWM group, which were treated with loading dose of sodium valproate and 1/2 loading dose of sodium valproate combined with 18 g of Chinese traditional medicine (TCM) (developed from the Lingjiao Gouteng decoction). The efficacy of TCM syndrome, epilepsy seizure frequency, Electroencephalogram (EEG), life quality, cognitive function and safety of each group were observed at the middle of and after treatment. Results found that, after treatment, the epilepsy seizure times in TCM-WM group were significantly less than control group (P<0.05). The total effective rate of TCM syndrome in TCM-WM group was 82.8%, which was significantly higher than 71.4% in control group (P<0.05). The total effective rates of EEG in TCM-WM group and control group were 82.7% and 57.1%, respectively, with significant difference between them (P<0.05). The life quality score in TCM-WM group was 24.91 ± 11.48, significantly lower than 29.46 ± 14.59 in control group (P<0.05), and the full-scale intelligence quotient in TCM-WM group was 84.73 ± 10.74, significantly than 69.26 ± 11.49 in control group (P<0.05). There was no obvious adverse reaction after treatment in each group. The TCM-WM integrated treatment has good efficacy and safety for patients with late-onset epilepsy after cerebral hemorrhage.