Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2017) Volume 28, Issue 18

Transforming growth factor-β1-509C/T polymorphism might be associated with chronic periodontitis risk

It is unclear whether there is significant association between TGF-β1-509C/T polymorphism and chronic periodontitis risk. Therefore, we performed this meta-analysis. We conducted a search through PubMed, Embase and the Web of Science. The associations between TGF-β1-509C/T polymorphism and chronic periodontitis risk as estimated using the OR and 95% CI. A total of 7 studies were included in this systematic review and meta-analysis. In the overall analysis, a significant association between the TGF- β1-509C/T polymorphism and chronic periodontitis risk was identified (OR=0.84; 95% CI, 0.71-1.00). When stratified by ethnicity, the TGF-β1-509C/T polymorphism showed a significant contribution to chronic periodontitis risk in the Asians (OR=0.80; 95% CI, 0.65-0.99). However, Caucasians with the TGF-β1-509C/T polymorphism did not show positive result (OR=0.94; 95% CI, 0.67-1.32). In the nonsmoker subgroup, no significant association was detected (OR=0.83; 95% CI, 0.60-1.15). In conclusion, this study suggested that TGF-β1-509C/T polymorphism was associated with chronic periodontitis risk.

Author(s): Zhen-Hui Wei, Yuan-Hong Du

Abstract Full Text PDF

Get the App