Biomedical Research

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To compare the healing of pressure sores by the use of combination therapy with platelet rich plasma and gelatin hydrogel versus platelet rich plasma and collagen

Aim and objective: To compare the healing of Pressure sores by combination therapy with platelet rich plasma and gelatin hydrogel versus combination therapy with a platelet rich plasma and collagen.

Material and method: The total sample size was comprised of 320 subjects. The sample was divided into two subgroups. First group received treatment with platelet rich plasma application with a gelatin sheet and second group received platelet rich plasma treatment with collagen ointment. Treatment with platelet rich plasma involves five steps starting from blood collection, centrifugation, separation of Platelet rich plasma, activation of coagulation process, placement of platelet rich plasma and covering with secondary dressing of either gelatin or collagen. The wound was dressed with this combination was review after 7 days, 4 weeks and 7 weeks.

Results: Primary outcome was reduction of ulcer at 7th day, 4th week and at 7th week interval. The depth, time of the depth of sore, closure of wound, CVIQ score, area of ulcer, and adverse effects/ complications were evaluated. Complete healing rates were almost same at 7th week between the PRP with gelatin hydrogel and PRP with Collagen. The results showed non-significant results for the complete healing of pressure sores between both the modalities. In the model, except ulcer depth, no one showed the significant prediction of complete healing within 7 weeks.

Conclusion: Both the combined modalities proved to be very successful in the healing of pressures sores. However, our research study found no difference in the healing outcome of pressures sores between the PRP with gelatin hydrogel and PRP with Collagen.

Author(s): Qian Yu, Fang-Jing Han, De-Sheng Lv