Research Article - Biomedical Research (2017) Volume 28, Issue 17
The value of coagulant molecular marker in diagnosis of cerebral infarction after intracerebral hemorrhage
Objective: To discover and analyze the value of coagulant molecular marker in diagnosis of cerebral infarction after intracerebral hemorrhage.
Methods: In this study, we selected a total of 42 patients with cerebral infarction after intracerebral hemorrhage as the experiment group; additionally, 42 patients with intracerebral hemorrhage were enrolled as the hemorrhage control group; besides, 42 healthy people that were confirmed through relevant examinations were selected as the healthy control group. For patients with intracerebral hemorrhage, before the onset of cerebral infarction, we detected a series of indicators, including plasma Fibrinogen (FIB), Hematocrit (HCT), and plasma Endothelin (ET-1), P-Selectin (P-S), Protein C (PC) and D-Dimer (D-D).
Results: In comparison of FIB and P-S, the values in the experiment group were significantly higher than those in the hemorrhage control group and the healthy control group, and the differences had statistical significance (p<0.05). While the values of D-D and ET-1 in the experiment group were significantly higher than those in the healthy control group (p<0.05), comparison of HCT showed that there was no statistically significant difference among three groups (p>0.05). However, the comparison of PC showed that the value in the experiment group was significantly lower than those in other two groups (p<0.05).
Conclusion: Detecting the levels of coagulant molecular markers in patients with intracerebral hemorrhage greatly contributes to the early diagnosis of secondary cerebral infarction and improvement in prognosis, which is worthy being promoted in clinical practice.Author(s): Xiaoliang Liu, Jiankang Ren, Yanli Su