Biomedical Research

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The neuro-protective effects of water extract of Faces Trogopterori on transient MCAO rats.

Objective: To get the water extracts of Faeces Trogopterori (WEFTs), and study its effect on Neurological function, inflammatory reaction and oxidative damage caused by ischemia-reperfusion injury of transient MCAO SD rats.\

Method: Neurological evaluation was conducted by modified Longa score, infarction volume percentage was calculated by TTC staining method and a normal method which has exclude the error of edema; SOD activity was tested by xanthine oxidase method, MDA content was determinate by TBA (Thiobarbituric acid) method, IL1-β level in brain tissue and serum in the ischemia-reperfusion rats was got by Elisa.

Result: There was no statistical difference between the score Faeces Trogopterori Groups and control group, but significant statistical difference there was between the two groups, infarction volume ratio of extracts groups was 35%, while the control group at 50%; Faeces Trogopterori group could significantly reduce the MDA content (p<0.01, vs model group), increased SOD activity (p<0.01, vs. model group).

Conclusion: Aqueous extract of Faeces Trogopterori could exert certain protective effect on ischemiareperfusion injury caused by MCAO rats.

Author(s): Qiaoling Zhai