Obesity and overweight have closely considered with several chronic diseases. Evidence of this field has demonstrated that significantly impact on the multiple cancers progression, such as breast cancer, prostate cancer, hepatocellular carcinoma, pancreatic cancer and cervical cancer. Epidemiological studies have shown that there is about 20% of cancer related to obesity, which were affected by lifestyle including dietary behavior and physical activity. Based on these findings, obesity is considered as one of most harmful factors for the breast cancer in women, especially after menopause. Many hypotheses have been proposed to explain how obesity contributes to breast cancer development. The inflammatory cytokines produced from adipocytes is one of main reason triggers tumor microenvironment and tumor progression. Better understanding the association between adipocytes and inflammation implanting breast tumor development could apply to develop new alternative methods for prevention/cure. In this review, we summarize the concept and evidence associated to interaction of obesity-driven changes and inflammation in breast cancer microenvironment.